NEUROPEPTIDE FF
- CAS No.
- 99566-27-5
- Chemical Name:
- NEUROPEPTIDE FF
- Synonyms
- NPFF;NPAF;ninamide;F-8-F-NH2;FLFQPQRF-NH2;NEUROPEPTIDE FF;Neuropeptide FF TFA;Neuropeptide FF (cattle);Neuropeptide FF F-8-F-NH2;NEUROPEPTIDE FF USP/EP/BP
- CBNumber:
- CB3750458
- Molecular Formula:
- C54H76N14O10
- Molecular Weight:
- 1081.27
- MDL Number:
- MFCD00076704
- MOL File:
- 99566-27-5.mol
NEUROPEPTIDE FF price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J66509 | Neuropeptide FF | 99566-27-5 | 1mg | $58.2 | 2023-06-20 | Buy |
Cayman Chemical | 24548 | Neuropeptide FF (trifluoroacetate salt) ≥95% | 99566-27-5 | 1mg | $158 | 2024-03-01 | Buy |
Tocris | 3137 | Neuropeptide FF | 99566-27-5 | 1 | $162 | 2021-12-16 | Buy |
Usbiological | 027103 | Neuropeptide FF | 99566-27-5 | 96Tests | $864 | 2021-12-16 | Buy |
Usbiological | 027102 | Neuropeptide FF | 99566-27-5 | 96Tests | $879 | 2021-12-16 | Buy |
NEUROPEPTIDE FF Chemical Properties,Uses,Production
Description
Neuropeptide FF (NPFF) is a peptide expressed in the brain and spinal cord that shares a precursor protein with neuropeptide AF. NPFF is expressed primarily in the posterior pituitary, hypothalamus, and medulla. It is an agonist at NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively, for human recombinant receptors) that inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively). NPFF activates parvocellular neurons in the paraventricular nucleus (PVN) of the hypothalamus to stimulate oxytocin release from their projections in the brain stem, thereby regulating baroreflex control of heart rate. However, it inhibits magnocellular PVN neurons by enhancing GABAergic input. It is also found in plasma and exogenous administration briefly increases mean arterial pressure (MAP) by 40 mm Hg in rats, an effect that is only partially blocked by the norepinephrine competitor guanethidine and the α1-adrenergic receptor antagonist prazosin . NPFF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats. It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol.
Uses
Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects.
storage
Store at -20°C
NEUROPEPTIDE FF Preparation Products And Raw materials
Raw materials
Preparation Products
NEUROPEPTIDE FF Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29824 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24099 | 58 |
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Go Top Peptide Biotech | 0571-88211921 | sales1@gotopbio.com | CHINA | 2609 | 58 |
Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
View Lastest Price from NEUROPEPTIDE FF manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-03-06 | NEUROPEPTIDE FF
99566-27-5
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
- NEUROPEPTIDE FF
99566-27-5
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co
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