(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
methylammonium chloride Structure](CAS/GIF/38176-02-2.gif)
- CAS No.
- 38176-02-2
- Chemical Name:
- (+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
- Synonyms
- LU 33925;NSC 632821;CCRIS 2680;R-Verapamil HCl;Verapamil impurity 31;Dexverapamil monohydrochloride;R(+)-Verapamil monohydrochloride;R(+)-Verapamil monohydrochloride hydrate;R(+)-Verapamil hydrate monohydrochloride;R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
- CBNumber:
- CB3931684
- Molecular Formula:
- C27H41ClN2O5
- Molecular Weight:
- 509.07784
- MDL Number:
- MFCD11046028
- MOL File:
- 38176-02-2.mol
- MSDS File:
- SDS
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Properties
| Melting point | 129-131?C |
|---|---|
| storage temp. | Refrigerator |
| solubility | H2O: >30mg/mL |
| form | powder |
| color | white |
| optical activity | [α]22/D +9.6°, c = 0.5 in ethanol(lit.) |
| FDA UNII | B0P742MK5O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331 |
| Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V106 | R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder | 38176-02-2 | 5mg | $268 | 2024-03-01 | Buy |
| Sigma-Aldrich | V106 | R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder | 38176-02-2 | 25mg | $1010 | 2024-03-01 | Buy |
| TRC | V124990 | (R)-(+)-VerapamilHydrochloride | 38176-02-2 | 2mg | $335 | 2021-12-16 | Buy |
| ChemScene | CS-0111666 | (R)-Verapamil(hydrochloride) 98.54% | 38176-02-2 | 10mg | $360 | 2021-12-16 | Buy |
| Biosynth Carbosynth | ID28684 | (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride | 38176-02-2 | 2mg | $578.1 | 2021-12-16 | Buy |
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties,Uses,Production
Chemical Properties
Colourless solid
Uses
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.
Uses
R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.
Definition
ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride.
Biochem/physiol Actions
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6854 | 65 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7856 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3421 | 58 |