Gepefrine
- CAS No.
- 18840-47-6
- Chemical Name:
- Gepefrine
- Synonyms
- Gepefrine;Unii-V51rrx51vh;Gepefrine [inn];Rivastigmine Impurity 25;(S)-3-(2-AMINOPROPYL)PHENOL;Phenol, 3-[(2S)-2-aminopropyl]-;Metaraminol Bitartrate Impurity 63
- CBNumber:
- CB41116643
- Molecular Formula:
- C9H13NO
- Molecular Weight:
- 151.21
- MDL Number:
- MOL File:
- 18840-47-6.mol
| Melting point | 155-158° |
|---|---|
| alpha | D25 +31.8° (c = 2 in methanol) |
| Boiling point | 281.0±15.0 °C(Predicted) |
| Density | 1.070±0.06 g/cm3(Predicted) |
| pka | 9.86±0.10(Predicted) |
| FDA UNII | V51RRX51VH |
| ATC code | C01CA15 |
Gepefrine Chemical Properties,Uses,Production
Originator
Pressionorm,Helopharm,W. Germany,1981
Manufacturing Process
Hydrolysis of D-(+)-1-(3-rnethoxyphenyl)-2-aminopropane: 2.42 mols (40 g)
of the compound are dissolved in 6N hydrochloric acid in a bomb tube
consisting of stainless steel and having a capacity of 500 ml. Hydrogen
chloride gas is passed into the ice-cooled solution until this is saturated, The
solution is then heated to 130°C for 2 hours in an air bath. After cooling and
driving off the hydrochloric acid at a slightly elevated temperature, the
hydrochloride of the 3-hydroxyphenyl derivative is present in the form of a
yellowish syrup.
The free base can be liberated from the hydrochloride by extracting a butanol
solution of the hydrochloride several times with sodium bicarbonate solution.
After recrystallization from isopropanol/ligroin, the yield of D-(+)-1-(3-
hydroxyphenyl)-2-aminopropane amounts to 33.0 g, corresponding to 90.1%
of theory relative to the D-form. Melting point = 152°C to 154°C.
Therapeutic Function
Antihypotensive
Gepefrine Preparation Products And Raw materials
Gepefrine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +86-0755-22677845 +86-13627253706 | sale@hdimpurity.com | China | 2285 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 13651849907; | xinyu_shi@jwypharmlab.com.cn | China | 12042 | 58 |
| Bejing Famous Pharmaceutical Technology Co., Ltd. | 13331045123 | 1963319514@qq.com | China | 14233 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19785 | 58 | |
| Henan Pumei Jihua Pharmaceutical Technology Co., Ltd. | 037188900765 18037465274 | enyawanglei@sina.cn | China | 13577 | 58 |
| Shandong Wadesen Biotechnology Co. LTD | 0531-88723173 18596073690 | 1047208234@qq.com | China | 3675 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 15347293736 | 2853117764@qq.com | China | 8594 | 58 |
| Cato Research Chemicals Inc. | 020-81960175-877 18933936954 | tianwen.zhan@cato-chem.com | China | 7722 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
| Shenzhen Qingtian Biotechnology Co, Ltd. | 18823167005 18162969855 | 744288988@qq.com | China | 2628 | 58 |
View Lastest Price from Gepefrine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | Metaraminol Bitartrate Impurity 63
18840-47-6
|
US $0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD |
-
- Metaraminol Bitartrate Impurity 63
18840-47-6
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD