게페프린

게페프린 C화학적 특성, 용도, 생산

Originator

Pressionorm,Helopharm,W. Germany,1981

Manufacturing Process

Hydrolysis of D-(+)-1-(3-rnethoxyphenyl)-2-aminopropane: 2.42 mols (40 g) of the compound are dissolved in 6N hydrochloric acid in a bomb tube consisting of stainless steel and having a capacity of 500 ml. Hydrogen chloride gas is passed into the ice-cooled solution until this is saturated, The solution is then heated to 130°C for 2 hours in an air bath. After cooling and driving off the hydrochloric acid at a slightly elevated temperature, the hydrochloride of the 3-hydroxyphenyl derivative is present in the form of a yellowish syrup.
The free base can be liberated from the hydrochloride by extracting a butanol solution of the hydrochloride several times with sodium bicarbonate solution. After recrystallization from isopropanol/ligroin, the yield of D-(+)-1-(3- hydroxyphenyl)-2-aminopropane amounts to 33.0 g, corresponding to 90.1% of theory relative to the D-form. Melting point = 152°C to 154°C.

Therapeutic Function

Antihypotensive

게페프린 준비 용품 및 원자재

원자재

준비 용품

게페프린 공급 업체

공급자	전화	이메일	국가	제품 수	이점
ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-0755-22677845 +86-13627253706	sale@hdimpurity.com	China	2384	58
JW & Y Pharmlab Co., Ltd.	021-64340559 13651849907;	xinyu_shi@jwypharmlab.com.cn	China	12041	58
Bejing Famous Pharmaceutical Technology Co., Ltd.	13331045123	1963319514@qq.com	China	14233	58
Shanghai zhigan biotechnology co., LTD		zhiqianbio@126.com	China	19785	58
Henan Pumei Jihua Pharmaceutical Technology Co., Ltd.	037188900765 18037465274	enyawanglei@sina.cn	China	13591	58
Shandong Wadesen Biotechnology Co. LTD	0531-88723173 18596073690	1047208234@qq.com	China	3682	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736 15347293736	2853117764@qq.com	China	8594	58
Cato Research Chemicals Inc.	020-81960175-877 18933936954	tianwen.zhan@cato-chem.com	China	7722	58
Shanghai Haohong Scientific Co., Ltd.	400-400-8210725	malulu@leyan.com	China	40041	58
Shenzhen Qingtian Biotechnology Co, Ltd.	18823167005 18162969855	744288988@qq.com	China	2628	58