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SANGUINARINE CHLORIDE

SANGUINARINE CHLORIDE structure

CAS No.: 5578-73-4

Chemical Name:: SANGUINARINE CHLORIDE

Synonyms: viadent;Sanguinarium;SANGUINARINE HCL;SANGUINARINE(SH);PSEUDOCHELERYTHRINE;SPECIOCILIATINE(SH);sanguinariumchloride;SANGUINARINE CHLORIDE;SANGUINARINE HCl hplc;Sanguinarine Choloride

CBNumber:: CB4228826

Molecular Formula:: C20H14ClNO4

Molecular Weight:: 367.78

MDL Number:: MFCD00012126

MOL File:: 5578-73-4.mol

Last updated:2023-06-30 15:45:59

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SANGUINARINE CHLORIDE Properties

Melting point	281-285°C
storage temp.	Inert atmosphere,2-8°C
solubility	methanol: 20 mg/mL, clear, orange
form	Orange solid.
color	Orange to Dark Orange
Stability	Hygroscopic, Light Sensitive
FDA UNII	B8Z8J4400H

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Risk Statements

Safety Statements

36-26

WGK Germany

RTECS

VP5220000

HS Code

29399990

NFPA 704

	0
2		0

SANGUINARINE CHLORIDE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S5890	Sanguinarine chloride hydrate ≥98% (HPLC)	5578-73-4	5mg	$172	2024-03-01	Buy
Sigma-Aldrich	S5890	Sanguinarine chloride hydrate ≥98% (HPLC)	5578-73-4	25mg	$685	2024-03-01	Buy
Cayman Chemical	16951	Sanguinarine (chloride) ≥98%	5578-73-4	1mg	$32	2024-03-01	Buy
Cayman Chemical	16951	Sanguinarine (chloride) ≥98%	5578-73-4	5mg	$93	2024-03-01	Buy
Cayman Chemical	16951	Sanguinarine (chloride) ≥98%	5578-73-4	10mg	$153	2024-03-01	Buy

Product number	Packaging	Price	Buy
S5890	5mg	$172	Buy
S5890	25mg	$685	Buy
16951	1mg	$32	Buy
16951	5mg	$93	Buy
16951	10mg	$153	Buy

SANGUINARINE CHLORIDE Chemical Properties,Uses,Production

Uses

antineoplastic, antiplaque agent

Uses

Sanguinarium Chloride is a natural product with antimicrobial, anti-inflammatory, and anti-oxidant properties. Sanguinarium Chloride has antiproliferative, pro-apoptosis effects in some cancer cell lines.

Uses

Sanguinarine chloride hydrate was tested for anti-schistosomal activities against Schistosoma mansoni.⁹ It was tested for anti-lipase activity against Candida rugosa lipase.¹⁰

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

sanguinarine chloride is a potent and specific inhibitor of pp2c with ki value of 0.68 μm, and is also a selective and cell-active inhibitor of mkp-1 with ic50 value of 10 μm. sanguinarine is also an allosteric activator of ampk [1][2][3].protein phosphatase 2c (pp2c) is a serine/threonine-specific phosphatase, the activity of which is dependent on mg2+ or mn2+. pp2c dephosphorylates a number of substrates such as cyclin-dependent kinase, mitogen-activated kinase (mapk) and bad. mitogen-activated protein kinase phosphatase-1 (mkp-1) is a dual specificity phosphatase. amp-activated protein kinase (ampk) plays an important role in the regulation of cellular metabolism [1][2][3].sanguinarine chloride is an inhibitor of pp2c and mkp-1, and also an allosteric activator of ampk with antibiotic and antitumor activity. sanguinarine competed with α-casein to inhibit pp2c and exhibited selectivity for pp2c as compared with pp1, pp2a and pp2b. in human promyelocytic leukemia cell line hl60, sanguinarine exhibited cytotoxicity with ic50 value of 0.37 μm and induced apoptosis via a caspase-3/7-dependent mechanism involving the phosphorylation of p38, a pp2c substrate [1]. sanguinarine inhibited mkp-1 and mkp-l with ic50 values of 17.3 and 12.5 μm. in panc-1 human pancreatic cancer cells, sanguinarine increased erk and jnk/sapk phosphorylation [2]. in the mda mb-231 cell line, sanguinarine caused ampk and the downstream acetyl-coa carboxylase (acc) phosphorylation [3]. in lncap and du145 cells, sanguinarine inhibited cell growth, induced g0/g1 phase arrest and apoptosis [4].

Biochem/physiol Actions

Sanguinarine is a benzophenanthridine alkaloid isolated from plants belonging to the family Papaveracea. It exhibits anti-bacterial, anti-fungal, anti-inflammatory and anti-cancer properties. It induces cell cycle arrest and sensitizes cancer cells to apoptosis by activating TNF-related apoptosis inducing ligand.6,7 It inhibits STAT3, MMP-2, MMP-9, interacts with glutathione, induces generation of ROS, disrupts the microtubule assembly and causes DNA damage resulting the death of the cancer cells.6,7,8

storage

Store at +4°C

References

[1]. aburai n, yoshida m, ohnishi m, et al. sanguinarine as a potent and specific inhibitor of protein phosphatase 2c in vitro and induces apoptosis via phosphorylation of p38 in hl60 cells. biosci biotechnol biochem, 2010, 74(3): 548-552.
[2]. vogt a, tamewitz a, skoko j, et al. the benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. j biol chem, 2005, 280(19): 19078-19086.
[3]. choi j, he n, sung mk, et al. sanguinarine is an allosteric activator of amp-activated protein kinase. biochem biophys res commun, 2011, 413(2): 259-263.
[4]. adhami vm, aziz mh, reagan-shaw sr, et al. sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. mol cancer ther, 2004, 3(8): 933-940.

SANGUINARINE CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

13-Methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridine-14(13H)-one

SANGUINARINE CHLORIDE Suppliers

Global( 224)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Xi'an Kono chem co., Ltd.,	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from SANGUINARINE CHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-24	Sanguinarine chloride 5578-73-4	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2022-02-14	Sanguinarine Chloride 5578-73-4 5578-73-4	US $15.00 / mg	20mg	≥98%	1000.00 kgs	NanJing Spring & Autumn Biological Engineering CO., LTD.
2019-07-06	SANGUINARINE CHLORIDE 5578-73-4	US $1.00-1.00 / kg	1 mg	99%	100KG	Career Henan Chemical Co

Sanguinarine chloride
5578-73-4
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Sanguinarine Chloride 5578-73-4
5578-73-4
US $15.00 / mg
≥98%
NanJing Spring & Autumn Biological Engineering CO., LTD.

SANGUINARINE CHLORIDE
5578-73-4
US $1.00-1.00 / kg
99%
Career Henan Chemical Co

SANGUINARINE CHLORIDE Spectrum

SANGUINARINE CHLORIDE(5578-73-4)¹HNMR

5578-73-4(SANGUINARINE CHLORIDE)Related Search:

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7-Hydroxyisoquinoline 2-Methoxynaphthalene quinoline,hydrochloride 2,3-Dihydroxynaphthalene 8-Isoquinolinol

SANGUINARINE CHLORIDE 7-METHOXY-ISOQUINOLINE 8-Methoxyisoquinoline 7,8-BENZOQUINOLINE Isoquinoline

Phenanthridine Sanguinarine citrate Ethoxysanguinarine

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SANGUINARINE CHLORIDE SANGUINARINE HCL PSEUDOCHELERYTHRINE PSEUDOCHELERYTHRINE CHLORIDE 13-METHYL-[1,3]BENZODIOXOLO[5,6-C]-1,3-DIOXOLO[4,5-I] PHENANTHRIDINIUM CHLORIDE Sanguinarine chloride, froM Macleaya cordata [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (1:1) 3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(chlo sanguinarinehydrochloride sanguinariumchloride viadent SANGUINARIN-CHLORID 97% Sanguinarium SANGUINARINE(SH) SANGUINARINE HCl hplc SPECIOCILIATINE(SH) Sanguinarine chloride hydrate, ≥98%(HPLC) Sanguinarine Chloride 5578-73-4 Sanguinarine chloride, 98%, from Macleaya cordata Sanguinarine chloride, 98%, from Macleaya cordata (Willd.) R. Br. 13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium chloride Sanguinarine Choloride 13-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium chloride 5578-73-4 C20H14ClNO4 C20H14NO4Cl Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates BioChemical Biochemicals and Reagents Cell Signaling and Neuroscience Cell Biology Ion Pump Inhibitors Ion Channels Monovalent Ion Channels Substrate Analogs Voltage-gated Ion Channels Inhibitors VIADENT Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals AlkaloidCancer Research Anti-proliferative AgentsVoltage-gated Ion Channels Ion Pump Inhibitors Biochemicals Found in Plants Chemopreventive Agents Monovalent Ion Channels Nutrition Research Alkaloids