5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
- CAS No.
- 1048371-03-4
- Chemical Name:
- 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
- Synonyms
- CS-874;UPF 1069;UPF 1069 10MG;UPF1069/UPF-1069;UPF 1069;UPF-1069; UPF1069;5-(2-Oxo-2-phenylethoxy)-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 5-(2-oxo-2-phenylethoxy)-;6H-Oxazolo[4,5-g][3]benzazepine, 7,8,9,10-tetrahydro-8-;5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one;5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one USP/EP/BP
- CBNumber:
- CB42518774
- Molecular Formula:
- C17H13NO3
- Molecular Weight:
- 279.29
- MDL Number:
- MFCD14051631
- MOL File:
- 1048371-03-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| NFPA 704 |
|
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17760 | UPF-1069 ≥98% | 1048371-03-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17760 | UPF-1069 ≥98% | 1048371-03-4 | 5mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 17760 | UPF-1069 ≥98% | 1048371-03-4 | 10mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 17760 | UPF-1069 ≥98% | 1048371-03-4 | 50mg | $381 | 2024-03-01 | Buy |
| TRC | U800095 | UPF1069 | 1048371-03-4 | 50mg | $455 | 2021-12-16 | Buy |
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Chemical Properties,Uses,Production
Description
UPF-1069 (1048371-03-4) is a selective PARP-2 inhibitor (IC50=0.3 μM and ~ 27-fold selective against PARP-1).1,2?Increases apoptosis in hippocampal slices but protects cortical cells in models of post-ischemic brain damage.3?Blocks the interaction between PARP-2 and FOXA1, attenuating androgen receptor-mediated gene expression and inhibiting androgen receptor-positive prostate cancer growth.4
Uses
UPF 1069, is a Selective PARP-2 inhibitor.
References
1) Pellicciari?et al.?(2008),?On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives; Chem. Med. Chem.,?3?914 2) Thorsell?et al.?(2017),?Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors; J. Med. Chem.,?60?1262 3) Moroni?et al.?(2009),?Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage; Br. J. Pharmacol.,?157?854 4) Gui?et al.?(2019),?Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function; Proc. Natl. Acad. Sci. USA,?116?14573
5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28812 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-23 | 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
1048371-03-4
|
US $1.00 / g | 100g | 99% | G/KG/T | Career Henan Chemical Co |
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- 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
1048371-03-4
- US $1.00 / g
- 99%
- Career Henan Chemical Co