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11107B

11107B structure

CAS No.: 445493-23-2

Chemical Name:: 11107B

Synonyms: 11107B;11107AD;PLADIENOLIDE B;SDOUORKJIJYJNW-VGQSKDSZSA-N;(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one;Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)-

CBNumber:: CB42666916

Molecular Formula:: C30H48O8

Molecular Weight:: 536.7

MDL Number:: MFCD22572773

MOL File:: 445493-23-2.mol

Last updated:2023-07-14 17:39:25

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11107B Properties

Boiling point	673.8±55.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form	A clear film
pka	13.98±0.70(Predicted)

11107B price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16538	Pladienolide B ≥95%	445493-23-2	100μg	$97	2024-03-01	Buy
Cayman Chemical	16538	Pladienolide B ≥95%	445493-23-2	500μg	$410	2024-03-01	Buy
Tocris	6070	PladienolideB ≥95%(HPLC)	445493-23-2	500U	$371	2021-12-16	Buy

Product number	Packaging	Price	Buy
16538	100μg	$97	Buy
16538	500μg	$410	Buy
6070	500U	$371	Buy

11107B Chemical Properties,Uses,Production

Uses

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome.

Uses

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

storage

Store at -20°C

11107B Preparation Products And Raw materials

Raw materials

Preparation Products

11107B Suppliers

Global( 21)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
AdooQ Bioscience CHINA	025-58849295 18951903616;	info@adooq.cn	China	2989	60
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3423	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55936	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
AdooQ Bioscience CHINA	60
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
Lynnchem	58
Novachemistry	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
BOC Sciences	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

11107AD 11107B PLADIENOLIDE B SDOUORKJIJYJNW-VGQSKDSZSA-N (4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one Oxacyclododec-9-en-2-one, 8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexadien-1-yl]-7,11-dimethyl-, (4R,7R,8S,9E,11S,12S)- 445493-23-2