CAS:932749-62-7
- CAS No.
- 932749-62-7
- Chemical Name:
- CAS:932749-62-7
- Synonyms
- CAS:932749-62-7;HAT Inhibitor II;Histone Acetyltransferase Inhibitor II;Histone Acetyltransferase Inhibitor II (compound 2c);2,6-Bis(3-bromo-4-hydroxybenzylidene)cyclohexan-1-one;Cyclohexanone, 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-;Histone Acetyltransferase,HeLa,H2B-EYFP,acetylation,inhibit,Histone Acetyltransferase Inhibitor II,HAT,anti-acetylase,Inhibitor,HATs,histones
- CBNumber:
- CB42741611
- Molecular Formula:
- C20H16Br2O3
- Molecular Weight:
- 464.15
- MDL Number:
- MFCD11655778
- MOL File:
- 932749-62-7.mol
- MSDS File:
- SDS
| Melting point | 201-202 °C(Solv: isopropanol (67-63-0); water (7732-18-5)) |
|---|---|
| Boiling point | 580.8±50.0 °C(Predicted) |
| Density | 1.733±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 7.89±0.35(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
CAS:932749-62-7 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19835 | HAT Inhibitor II ≥98% | 932749-62-7 | 10mg | $213 | 2024-03-01 | Buy |
| Usbiological | 451941 | Histone Acetyltransferase Inhibitor II | 932749-62-7 | 10mg | $516 | 2021-12-16 | Buy |
| TRC | H456345 | HistoneAcetyltransferaseInhibitorII | 932749-62-7 | 25mg | $400 | 2021-12-16 | Buy |
CAS:932749-62-7 Chemical Properties,Uses,Production
Uses
Histone Acetyltransferase Inhibitor II is a selective, cell-permeable p300/CBP HAT inhibitor, which may be used in the treatement of cystic fibrosis.
Biological Activity
hat inhibitor ii, a cell-permeable bis-arylidene cyclohexanone compound, selectively inhibits the histone acetyltransferase p300/creb-binding protein (cbp) with an ic50 value of 5 μm. it affects gcn5 and pcaf acetyltransferases only at much higher concentrations.histone acetyltransferase p300, a ubiquitously expressed global transcriptional coactivator, plays critical roles in a wide variety of cellular phenomena, involving in cell cycle control, differentiation, and apoptosis.
in vitro
hat inhibitor ii dose-dependently suppressed the proliferation of u251, u87, hs683 and shg44 cells. in hat inhibitor ii-treated u251 and shg44 cells, cell cycle arrest at the g2/m phase was triggered by hat inhibitor ii, significant levels of apoptosis, apoptotic body formation and dna fragmentation were induced, and cleavage of caspase-3, caspase-9 and parp were caused. additionally, hat inhibitor ii upregulated 965 genes and downregulated 984 genes in hat inhibitor ii-treated u251 cells [1].
in vivo
c57bl/6j mice were intraperitoneally administrated with hat inhibitor ii at a dose of 185 μg/g for 15 min. in muscle early postmortem, hat inhibitor ii inhibited protein acetylation, which reduced amp-activated protein kinase activation induced increase in the total acetylated proteins as well as glycolytic rate [2].
References
[1]. xu, l., li, z., tao, y., li, r., fang, f., & zhao, h. et al. histone acetyltransferase inhibitor ii induces apoptosis in glioma cell lines via the p53 signaling pathway. journal of experimental & clinical cancer research. 2014; 33:108.
[2]. li, q., li, z., lou, a., wang, z., zhang, d., & shen, q. histone acetyltransferase inhibitors antagonize amp-activated protein kinase in postmortem glycolysis. asian-australasian journal of animal sciences. 2016; 30(6): 857-864.
CAS:932749-62-7 Preparation Products And Raw materials
Raw materials
Preparation Products
CAS:932749-62-7 Suppliers
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