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Hesperetin

Hesperetin structure

CAS No.: 520-33-2

Chemical Name:: Hesperetin

Synonyms: (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-;YSO2;NSC 57654;HESPERETIN;HESPERETINE;HESPERETIN(P);Hesperetin>Prestwick_908

CBNumber:: CB4304735

Molecular Formula:: C16H14O6

Molecular Weight:: 302.28

MDL Number:: MFCD00075646

MOL File:: 520-33-2.mol

MSDS File:: SDS

Last updated:2024-04-01 21:53:03

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Hesperetin Properties

Melting point	230-232°C
Boiling point	363.32°C (rough estimate)
Density	1.2514 (rough estimate)
refractive index	-4 ° (C=1.8, EtOH)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.49±0.40(Predicted)
form	Solid
color	White to Pale Yellow
Water Solubility	Soluble in water (partly), dilute alkalis, and ethanol (50 mg/ml).
Merck	14,4670
BRN	309850
InChIKey	AIONOLUJZLIMTK-AWEZNQCLSA-N
LogP	2.90
Substances Added to Food (formerly EAFUS)	5,7-DIHYDROXY-2-(3-HYDROXY-4-METHXY-PHENYL)-CHROMAN-4-ONE
CAS DataBase Reference	520-33-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	Q9Q3D557F1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39-27-37

WGK Germany

HS Code

29329990

NFPA 704

	1
2		0

Hesperetin price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	H0721	Hesperetin >97.0%(HPLC)(T)	520-33-2	5g	$17	2024-03-01	Buy
TCI Chemical	H0721	Hesperetin >97.0%(HPLC)(T)	520-33-2	25g	$49	2024-03-01	Buy
Alfa Aesar	B20528	3',5,7-Trihydroxy-4'-methoxyflavanone, 97%	520-33-2	1g	$30.65	2024-03-01	Buy
Alfa Aesar	B20528	3',5,7-Trihydroxy-4'-methoxyflavanone, 97%	520-33-2	5g	$88.65	2024-03-01	Buy
Alfa Aesar	B20528	3',5,7-Trihydroxy-4'-methoxyflavanone, 97%	520-33-2	25g	$345.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
H0721	5g	$17	Buy
H0721	25g	$49	Buy
B20528	1g	$30.65	Buy
B20528	5g	$88.65	Buy
B20528	25g	$345.65	Buy

Hesperetin Chemical Properties,Uses,Production

Description

Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC₅₀ = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.

Chemical Properties

Beige to Light Brown Crystalline Solid

Uses

antiallergic

Uses

The aglucon of Hesperidin (H281185), a flavanone found in citrus fruits.

Uses

(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.

Definition

ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).

Purification Methods

Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

Hesperetin synthesis

Synthesis of Hesperetin from Hesperidin

Hesperetin Preparation Products And Raw materials

Raw materials

Preparation Products

BETA-PHENYLPROPIOPHENONE Neosperidin dihydrochalcone rac-Hesperetin 3’,7-Diacetate

Hesperetin Suppliers

Global( 424)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changsha Staherb Natural Ingredients Co., Ltd.	+86-0731-84213302 +8618374838656	sales@staherb.cn	China	1025	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58

Supplier	Advantage
Changsha Staherb Natural Ingredients Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
Shaanxi Pioneer Biotech Co., Ltd .	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58

View Lastest Price from Hesperetin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-28	Hesperetin 520-33-2	US $10.00 / kg	1kg	90%,95%,98%HPLC	10000	Changsha Staherb Natural Ingredients Co., Ltd.
2024-04-28	Hesperetin 520-33-2	US $100.00 / kg	1kg	98%	10000	Changsha Staherb Natural Ingredients Co., Ltd.
2024-04-22	Hesperetin 520-33-2	US $0.00 / kg	1kg	99.8%	1000 kg	BINBO BIOLOGICAL CO.,LTD

Hesperetin
520-33-2
US $10.00 / kg
90%,95%,98%HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

Hesperetin
520-33-2
US $100.00 / kg
98%
Changsha Staherb Natural Ingredients Co., Ltd.

Hesperetin
520-33-2
US $0.00 / kg
99.8%
BINBO BIOLOGICAL CO.,LTD

Hesperetin Spectrum

HESPERETIN(520-33-2)MS HESPERETIN(520-33-2)¹HNMR HESPERETIN(520-33-2)¹³CNMR HESPERETIN(520-33-2)IR1 HESPERETIN(520-33-2)IR2

520-33-2(Hesperetin)Related Search:

HESPERETIN-7-NEOHESPERIDOSIDE hplc,Neohesperidin，Hesperetin 7-neohesperidoside,HESPERETIN-7-NEOHESPERIDOSIDE,HESPERETIN-7-O-NEOHESPERIDOSIDE Paeoniflorin Quercetin dihydrate Naringin Resveratrol

Ferulic Acid Citric acid Luteolin (+/-)-HESPERETIN,HESPERETIN hesperetin,7-(6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside

HESPERETIN LAURATE 4'-METHOXYFLAVANONE HESPERETIN, [3H(G)] HESPERETIN DIHYDROCHALCONE hesperetin 5-O-glucoside

4'-METHOXYFLAVANONE HESPERETIN CHALCONE HESPERETIN DIHYDROCHALCONE(RG)

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4'-METHOXY-3',5,7-TRIHYDROXYFLAVANONE (+/-)-3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE 3',5,7-TRIHYDROXY-4'-METHOXYFLAVANONE 3',5,7-TRIHYDROXY-4-METHOXYFLAVANONE 5,7,3'-TRIHYDROXY-4'-METHOXYFLAVANONE HESPERETINE (+/-)-HESPERETIN HESPERETIN HESPERETIN 97% 5,7-DIHYDROXY-2-(3-HYDROXY-4-METHOXY-PHENYL)-CHROMAN-4-ONE (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one HESPERETIN(P) HESPERETIN hplc HESPERETIN WITH HPLC (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one (2S)-2-(3-Hydroxy-4-methoxyphenyl)-5,7-dihydroxy-2H-1-benzopyran-4(3H)-one (S)-3',5,7-Trihydroxy-4'-methoxyflavanone [S,(-)]-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Eriodictyol 4'-monomethyl ether (2S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-Methoxyphenyl)-4H-1-benzopyran-4-one NSC 57654 (S)-5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one 2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one Diosmin Impurity G Nano Liposomal Hesperetin Hesperetin 520-33-2 Diosmin ep imp G Hesperetin> (S)-Hesperetin Hesperetin Discontinued. Please see H289480 or H289501 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one hesperetin extract (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyron 2,3-DIHYDRO-5,7-DIHYDROXY-2S-(3-HYDROXY-4-METHOXPHENYL)-4H-1-BENZOPYRAN-4-ONE (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- Hesperitin（mixture of isomers） 13C,2H3]-Hesperetin Hesperetin (6CI) (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (hesperetin). Hesperetin (diosmine EP impurity G) Prestwick_908 YSO2 520-33-2 C16H14O6 Flavonoids HA -HT Analytical Standards Alphabetic Analytical Chromatography Product Catalog natural product chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Chiral Reagents Intermediates & Fine Chemicals