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JH-II-127

JH-II-127 Structure
JH-II-127 structure
CAS No.
1700693-08-8
Chemical Name:
JH-II-127
Synonyms
JH-II-127;2-anilino-4-methylamino-5-chloropyrrolopyrimidine;2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127;(4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone;Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-;HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T
CBNumber:
CB43049255
Molecular Formula:
C19H21ClN6O3
Molecular Weight:
416.86
MDL Number:
MFCD28975160
MOL File:
1700693-08-8.mol
Last updated:2023-09-20 16:43:00
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JH-II-127 Properties

Melting point >166°C (dec.)
Density 1.458±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.49±0.50(Predicted)
color White to Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P261-P305+P351+P338

JH-II-127 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2569 JH-II-127 ≥98% (HPLC) 1700693-08-8 5MG $123 2024-03-01 Buy
Sigma-Aldrich SML2569 JH-II-127 ≥98% (HPLC) 1700693-08-8 25MG $396 2024-03-01 Buy
Cayman Chemical 22905 JH-II-127 1700693-08-8 1mg $32 2024-03-01 Buy
Cayman Chemical 22905 JH-II-127 1700693-08-8 5mg $139 2024-03-01 Buy
Cayman Chemical 22905 JH-II-127 1700693-08-8 10mg $243 2024-03-01 Buy
Product number Packaging Price Buy
SML2569 5MG $123 Buy
SML2569 25MG $396 Buy
22905 1mg $32 Buy
22905 5mg $139 Buy
22905 10mg $243 Buy

JH-II-127 Chemical Properties,Uses,Production

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

Uses

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

storage

Store at -20°C

JH-II-127 Preparation Products And Raw materials

Raw materials

Preparation Products

JH-II-127 Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9635 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Finetech Industry Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58

View Lastest Price from JH-II-127 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JH-II-127 pictures 2019-12-27 JH-II-127
1700693-08-8
 US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • JH-II-127 pictures
  • JH-II-127
    1700693-08-8
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co

JH-II-127 Spectrum

JH-II-127(1700693-08-8)1HNMR
JH-II-127 (4-((5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholi (4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone 2-anilino-4-methylamino-5-chloropyrrolopyrimidine 2-ANILINO-4-METHYLAMINO-5-CHLOROPYRROLOPYRIMIDINE;JH-II127;JH-II 127 [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone Methanone, [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl- [4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone HEK293,JHII127,3T3 cells,Inhibitor,LRRK2-G2019S,Ser935,Leucine-rich repeat kinase 2,LRRK2,parkinson’s disease,inhibit,JH II 127,LRRK2-A2016T 1700693-08-8