KJ Pyr 9
- CAS No.
- 581073-80-5
- Chemical Name:
- KJ Pyr 9
- Synonyms
- KJ Pyrq;KJ Pyr 9;4-[2-(2-Furyl)-6-(4-nitrophenyl)-4-pyridyl]benzamide;4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide;4-(2-(Furan-2-yl)-6-(4-nitrophenyl)pyridin-4-yl)benzamide;Benzamide, 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-;c-Myc,KJ Pyr9,inhibit,Autophagy,Inhibitor,Myc,KJ Pyr 9,KJ Pyr-9
- CBNumber:
- CB43122345
- Molecular Formula:
- C22H15N3O4
- Molecular Weight:
- 385.37
- MDL Number:
- MOL File:
- 581073-80-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
KJ Pyr 9 price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19116 | KJ Pyr 9 ≥98% | 581073-80-5 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 19116 | KJ Pyr 9 ≥98% | 581073-80-5 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 19116 | KJ Pyr 9 ≥98% | 581073-80-5 | 10mg | $122 | 2024-03-01 | Buy |
Cayman Chemical | 19116 | KJ Pyr 9 ≥98% | 581073-80-5 | 25mg | $267 | 2024-03-01 | Buy |
Tocris | 5306 | KJPyr9 ≥98%(HPLC) | 581073-80-5 | 50 | $520 | 2021-12-16 | Buy |
KJ Pyr 9 Chemical Properties,Uses,Production
Uses
4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide is a inhibits MYC-induced oncogenic transformation in cell culture and blocks the growth of a xenotransplant of MYC-amplified human cancer cells.
Biological Activity
mkj pyr 9 is a novel small molecule inhibitor of myc, with the kd value of 6.5 ± 1.0 nm. besides, kj pyr 9 also suppresses the formation of myc-max and oncogenic transformation induced by myc in cell culture [1].
in vitro
in chicken embryo fibroblasts, kj pyr 9 was found to have the ability to interfere with the oncogenic activity of myc, with the best aqueous solubility. besides, in human b-cell line p493-6, 20 μm kj pyr 9 could significantly inhibit cell proliferation, and kj pyr 9 could also inhibit the proliferation of nci-h460, mda-mb-231, and sum-159pt cell lines, with the ic50 values between 5-10 μm. furthermore, treatment of p493-6 cells with kj pyr 9 could significantly suppress the transcription ability of myc [1].
in vivo
kj pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. besides, in a mda-mb-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg kj pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1].
target
myc
storage
Store at +4°C
References
[1] hart j r, garner a l, yu j, et al. inhibitor of myc identified in a kröhnke pyridine library[j]. proceedings of the national academy of sciences, 2014, 111(34): 12556-12561.
KJ Pyr 9 Preparation Products And Raw materials
Raw materials
Preparation Products
KJ Pyr 9 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 2698 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3445 | 55 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2985 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |