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DEFEROXAMINE MESYLATE

DEFEROXAMINE MESYLATE Structure
DEFEROXAMINE MESYLATE structure
CAS No.
138-14-7
Chemical Name:
DEFEROXAMINE MESYLATE
Synonyms
DFOM;desferal;DESFERRIOXAMINE MESYLATE;deferoxaminebmesylate;Desferioxamine mesylate;desferrioxamine mesilate;DEFEROXAMINE MESYLATE SALT;Prestwick_988;desferalmesylate;deferoxaminemesilate
CBNumber:
CB4372020
Molecular Formula:
C26H52N6O11S
Molecular Weight:
656.79
MDL Number:
MFCD00058605
MOL File:
138-14-7.mol
MSDS File:
SDS
Last updated:2024-04-24 17:21:45
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DEFEROXAMINE MESYLATE Properties

Melting point 148-149°
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form powder
color white to off-white
Water Solubility Soluble to 100 mM in water
FDA UNII V9TKO7EO6K
NCI Drug Dictionary deferoxamine mesylate

Pharmacokinetic data

Protein binding <10%
Excreted unchanged in urine 22%
Volume of distribution 2-2.5(L/kg)
Biological half-life 6 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  22-24/25
WGK Germany  2
RTECS  UG5310000
HS Code  29280000
Toxicity man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

DEFEROXAMINE MESYLATE price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D9533 Deferoxamine mesylate salt powder, ≥92.5% (TLC) 138-14-7 1g $142 2024-03-01 Buy
Sigma-Aldrich 252750 Deferoxamine Mesylate - CAS 138-14-7 - Calbiochem Parenteralironchelatingagent.Commonlyusedintherapyasachelatorofferri 138-14-7 1g $210 2024-03-01 Buy
Sigma-Aldrich 1166003 Deferoxamine mesylate United States Pharmacopeia (USP) Reference Standard 138-14-7 300mg $436 2024-03-01 Buy
Sigma-Aldrich Y0001934 Deferoxamine for system suitability European Pharmacopoeia (EP) Reference Standard 138-14-7 Y0001934 $218 2023-06-20 Buy
Cayman Chemical 14595 Deferoxamine (mesylate) ≥95% 138-14-7 500mg $73 2024-03-01 Buy
Product number Packaging Price Buy
D9533 1g $142 Buy
252750 1g $210 Buy
1166003 300mg $436 Buy
Y0001934 Y0001934 $218 Buy
14595 500mg $73 Buy

DEFEROXAMINE MESYLATE Chemical Properties,Uses,Production

Description

Deferoxamine is a bacterial siderophore that chelates iron. It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 μM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia. Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.

Chemical Properties

DEFEROXAMINE MESYLATE is white or almost white powder.

Uses

DEFEROXAMINE MESYLATE is an iron chelating agent used in therapy for patients with sickle cell diseases and iron overload. Studies suggest that it can exert potential antioxidant neuroprotective effects in stroke patients

Uses

chelating agent (Fe & Al)

brand name

Desferal (Novartis).

Biochem/physiol Actions

An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.

Clinical Use

Chelating agent:
Acute iron poisoning
Chronic iron or aluminium overload

Veterinary Drugs and Treatments

Deferoxamine is used for the treatment of either acute or chronic iron toxicity. It is being evaluated as an iron chelator for adjunctive treatment of acute cardiac ischemia and as a chelator for aluminum toxicity. Its efficacy in treating reperfusion injuries has been disappointing.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid prochlorperazine, levomepromazine and methotrimeprazine (prolonged unconsciousness).
Do not administer with blood.

Metabolism

When given parenterally desferrioxamine forms chelates with iron and aluminium ions to form ferrioxamine and aluminoxamine, respectively. The chelates are excreted in the urine and faeces via the bile. Desferrioxamine is metabolised, mainly in the plasma. Four metabolites of desferrioxamine were isolated from urine of patients with iron overload. The following biotransformation reactions were found to occur with desferrioxamine: transamination and oxidation yielding an acid metabolite, beta-oxidation also yielding an acid metabolite, decarboxylation and N-hydroxylation yielding neutral metabolites.

storage

Store at -20°C

DEFEROXAMINE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

DEFEROXAMINE MESYLATE Suppliers

Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7934 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12527 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9271 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58

View Lastest Price from DEFEROXAMINE MESYLATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DEFEROXAMINE MESYLATE pictures 2024-04-24 DEFEROXAMINE MESYLATE
138-14-7
 US $8.00-2.00 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
DeferoxaMine Mesylate pictures 2022-02-19 DeferoxaMine Mesylate
138-14-7
 US $0.00 / KG 1KG 98.4% 100 tons Honest Joy Holdings Limited
DEFEROXAMINE MESYLATE USP/EP/BP pictures 2021-08-14 DEFEROXAMINE MESYLATE USP/EP/BP
138-14-7
 US $1.10 / g 1g 0.999 100 Tons min Dideu Industries Group Limited

DEFEROXAMINE MESYLATE Spectrum

DEFEROXAMINE MESYLATE(138-14-7)MSDEFEROXAMINE MESYLATE(138-14-7)1HNMR

138-14-7(DEFEROXAMINE MESYLATE)Related Search:

Hydroxyurea Deferoxamine AMMONIUM FERRIC CHLORIDE Ammonium ferric sulfate dodecahydrate Ferric ammonium EDTA
Ferrous ammonium sulfate hexahydrate AMMONIUM IRON (III) HEXACYANOFERRATE (II) Ferric ammonium citrate,brown Ammonium iron(III) sulfate Ferric ammonium oxalate
MAFA Ammonium ferric citrate Ferric ammonium oxalate trihydrate DEFEROXAMINE MESYLATE NOCARDAMINE
ferrimycin A1 MAFA aqueous solution (5%) Deferoxamine Mesylate Salt

1of4

deferoxaminemesilate deferoxaminemethanesulfonate desferalmesylate desferalmethanesulfonate desferrioxaminebmesylate Deferoxamine Mesylate (300 mg) N-[5-[3-[(5-aMinopentyl)hydroxycarbaMoyl]propionaMido]pentyl]-3-[[5-(N-hydroxyacetaMido) N1-(5-aMinopentyl)-N1-hydroxy-N4-[5-[[4-[[5-(acetylhydroxyaMino)pentyl]aMino]-1,4-dioxobutyl]hydroxyaMino]pentyl]butanediaMide Methanesulfonate desferrioxaminebmethanesulfonate monomethanesulfonate(sa propionohydroxamicacid,n-(5-(3-((5-aminopentyl)hydroxycarbamoyl)propionamido) Butanediamide, N-5-4-5-(acetylhydroxyamino)pentylamino-1,4-dioxobutylhydroxyaminopentyl-N-(5-aminopentyl)-N-hydroxy-, monomethanesulfonate (salt) STARCHDEFEROXAMINECONJUGATE Desferrioxamine mesylate salt Prestwick_988 Deferoxamine mesylate salt,DFOM, Deferoxamine methanesulfonate salt, Desferrioxamine mesylate salt Deferoxamine Mesylate (500 mg) DEFEROXAMINE METHANESULFONATE SALT DEFEROXAMINE MESYLATE N4-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino-1,4-dioxobutyl]hydroxyamino]pentyl]-N1-(5-aminopentyl)-N1-hydroxybutanediamide methanesulfonate Deferoxamine Mesilate RS Deferoxamine mesilate CRS Deferoxamine for system suitability DEFEROXAMINE MESYLATE USP/EP/BP Deferoxamine Mesylate (1166003) deferoxaminebmesylate desferal DFOM DESFERRIOXAMINE MESYLATE DEFEROXAMINE MESYLATE SALT Desferioxamine mesylate desferrioxamine mesilate esferrioxamineBmesylate N1-(5-(4-((5-Aminopentyl)amino)-4-oxobutanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxyacetamido)pentyl)succinamide methanesulfonate HIFs,neovascularization,TAMSCs,diabetes mellitus,Akt,PKB,Protein kinase B,Apoptosis,Autophagy,SH-SY5Y,Hypoxia-inducible factors,Deferoxamine,Deferoxamine Mesylate,Inhibitor,MEFs,cancer,Alzheimer’s disease,HIF-PH,Reactive Oxygen Species,BMMSCs,inhibit,HIF/HIF Prolyl-Hydroxylase,COVID-19 Deferiprone Impurity 3 Deferoxamine mesylate USP/Ph. Eur 138-14-7 C26H52N6O11S C25H48N6O8CH4O3S C25H48N6O8CH4SO3 Inhibitors DESFERAL Pharmaceuticals Aliphatics Amines Chelating Agents & Ligands Intermediates & Fine Chemicals