ChemicalBook >> CAS DataBase List >>PF-06446846 HYDROCHLORIDE
PF-06446846 HYDROCHLORIDE
- CAS No.
- 1632250-50-0
- Chemical Name:
- PF-06446846 HYDROCHLORIDE
- Synonyms
- PF 6446846 hydrochloride;PF-06446846 HYDROCHLORIDE;PF-06446846 hydrochloride >=98% (HPLC);PF06446846 hydrochloride,PF 06446846 hydrochloride;(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride;N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
- CBNumber:
- CB44744339
- Molecular Formula:
- C22H21Cl2N7O
- Molecular Weight:
- 470.36
- MDL Number:
- MOL File:
- 1632250-50-0.mol
Last updated:2023-09-04 15:51:00
PF-06446846 HYDROCHLORIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0374 | PF-06446846 hydrochloride ≥98% (HPLC) | 1632250-50-0 | 5mg | $100.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0374 | PF-06446846 hydrochloride ≥98% (HPLC) | 1632250-50-0 | 25mg | $674 | 2024-03-01 | Buy |
| ChemScene | CS-0085754 | PF-06446846 hydrochloride 98.03% | 1632250-50-0 | 50mg | $1200 | 2021-12-16 | Buy |
| ChemScene | CS-0085754 | PF-06446846 hydrochloride 98.03% | 1632250-50-0 | 100mg | $2100 | 2021-12-16 | Buy |
| ChemScene | CS-0085754 | PF-06446846 hydrochloride 98.03% | 1632250-50-0 | 5mg | $250 | 2021-12-16 | Buy |
PF-06446846 HYDROCHLORIDE Chemical Properties,Uses,Production
Biological Activity
PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.
in vitro
PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC 50 of 0.3 μM.
in vivo
PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.
| Animal Model: | Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing) |
| Dosage: | 5, 15, and 50 mg/kg |
| Administration: | Oral gavage; daily for 14 days |
| Result: | Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels. |
target
PCSK9
PF-06446846 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06446846 HYDROCHLORIDE Suppliers
Global( 22)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9747 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 879 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
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PF-06446846 HYDROCHLORIDE
N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide hydrochloride
PF 6446846 hydrochloride
PF-06446846 hydrochloride >=98% (HPLC)
PF06446846 hydrochloride,PF 06446846 hydrochloride
(R)-4-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl)benzamide xhydrochloride
1632250-50-0