Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Structure
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- structure
CAS No.
2138300-40-8
Chemical Name:
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-
Synonyms
STING agonist-4;diABZI STING Agonist-2;1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-;1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI);TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA
CBNumber:
CB45479775
Molecular Formula:
C34H38N12O4
Molecular Weight:
678.74
MDL Number:
MFCD32197200
MOL File:
2138300-40-8.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Properties

Density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: slightly soluble
form A solid
pka 11.97±0.43(Predicted)

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0087594 STINGagonist-4 99.52% 2138300-40-8 5mg $420 2021-12-16 Buy
ChemScene CS-0087594 STINGagonist-4 99.52% 2138300-40-8 10mg $600 2021-12-16 Buy
ChemScene CS-0087594 STINGagonist-4 99.52% 2138300-40-8 50mg $1800 2021-12-16 Buy
ChemScene CS-0087594 STINGagonist-4 99.52% 2138300-40-8 100mg $2520 2021-12-16 Buy
DC Chemicals DC12505 STINGagonist-4 >98% 2138300-40-8 50mg $1600 2021-12-16 Buy
Product number Packaging Price Buy
CS-0087594 5mg $420 Buy
CS-0087594 10mg $600 Buy
CS-0087594 50mg $1800 Buy
CS-0087594 100mg $2520 Buy
DC12505 50mg $1600 Buy

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Chemical Properties,Uses,Production

Biological Activity

STING agonist-4 is a stimulator of receptor agonists of the interferon gene (STING) with an apparent inhibition constant IC50 of 20 nM, It is a compound containing two symmetrically related aminobenzimidazoles (ABZI ) based compounds.

in vitro

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC 50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K d < /sub> ) of approximately 1.6 nM. It (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC 50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.

Cell Viability Assay

< td class="col1"> Result:
Cell Line: Human peripheral blood mononucl ear cells (PBMCs)
Concentration: 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM
Incubation Time: 2 hours
Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β.

target

IC50: 20 nM (STING agonist-4)

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Suzhou Su Taike Biological Reagent Co., Ltd. 0512-0512-65884469 18352410772 seetech@126.com China 4 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3422 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4153 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
Heze Development Zone chuangli Chemical Co., Ltd. +86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 875 55
Suzhou Su Taike Biological Reagent Co., Ltd. 18352410772 seetech@126.com China 6 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
BOC Sciences -- info@bocsci.com USA 0 65
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Suzhou Su Taike Biological Reagent Co., Ltd. 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Heze Development Zone chuangli Chemical Co., Ltd. 55
Suzhou Su Taike Biological Reagent Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
BOC Sciences 65
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- STING agonist-4 TMEM173,STING agonist-4,MPYS,Inhibitor,STING agonist 4,STING,Stimulator of Interferon Genes,inhibit,ERIS,STING agonist4,MITA diABZI STING Agonist-2 1H-Benzimidazole-5-carboxamide, 1,1′-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- (ACI) 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide 2138300-40-8 213830-40-8 C34H38N12O4