Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Structure
Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] structure
CAS No.
221111-70-2
Chemical Name:
Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]
Synonyms
Beauveriolide III;Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl]
CBNumber:
CB48391665
Molecular Formula:
C27H41N3O5
Molecular Weight:
487.64
MDL Number:
MOL File:
221111-70-2.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Properties

Melting point 246-248 °C
Boiling point 777.3±60.0 °C(Predicted)
Density 1.050±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble,Methanol: soluble
pka 13.12±0.70(Predicted)

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Chemical Properties,Uses,Production

Biological Activity

Beauveriolide III is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.1 It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50 = 0.41 μM), in primary mouse peritoneal macrophages.1,2 Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 5.5 μM).2 Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic atherosclerotic lesions in Ldlr-/- and ApoE-/- mouse models of atherosclerosis.

References

1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979J. Antibiot. (Tokyo)52(1)1-6(1999) 2.Namatame, I., Tomoda, H., Ishibashi, S., et al.Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophagesProc. Nat. Acad. Sci. USA101(3)737-742(2004)

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19743 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Zhejiang Huida Biotech Co., LTD 0571-89903882 13626641628 jiangnan@huidabiotech.com China 3656 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Zhejiang Huida Biotech Co., LTD 0571-0571-89903882 15990081639 sunshixuan@huidabiotech.com China 3705 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
Hangzhou Huiyi Biotechnology Co., LTD 0571-89918262 13357170655 chenlingwei@hizyme.com China 587 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
BOC Sciences 		58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhejiang Huida Biotech Co., LTD 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Zhejiang Huida Biotech Co., LTD 58
Beijing Biocreative Technology Co., Ltd. 58
Hangzhou Huiyi Biotechnology Co., LTD 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Cyclo[L-alanyl-D-alloisoleucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] Beauveriolide III 221111-70-2