2'-Deoxy-2'-fluoroguanosine
- CAS No.
- 78842-13-4
- Chemical Name:
- 2'-Deoxy-2'-fluoroguanosine
- Synonyms
- 2'-F-G;2'-FdG;2'-F-2'-dG;Guanosine Impurity 9;2'-F-2'-deoxyguanosine;2'-deoxy-2'-fluoroguanosine;2'-Fluoro-2'-deoxyguanosine;2'-Deoxy-2'-fluoroguanosine;2'-Fluoro -2'-deoxyguanosine;Guanosine,2'-deoxy-2'-fluoro-
- CBNumber:
- CB51231453
- Molecular Formula:
- C10H12FN5O4
- Molecular Weight:
- 285.23
- MDL Number:
- MFCD00923832
- MOL File:
- 78842-13-4.mol
- MSDS File:
- SDS
| Melting point | 262-264 °C(Solv: water (7732-18-5)) |
|---|---|
| Density | 2.17±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO : 50 mg/mL (175.30 mM) |
| pka | 9?+-.0.20(Predicted) |
| form | Powder |
| color | White to Off-white |
| InChI | InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1 |
| InChIKey | UXUZARPLRQRNNX-DXTOWSMRSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](F)[C@@H]1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| HS Code | 2934999090 |
2'-Deoxy-2'-fluoroguanosine price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64055 | 2'-Fluoro-2'-deoxyguanosine 99% | 78842-13-4 | 250mg | $32.65 | 2024-03-01 | Buy |
| Alfa Aesar | J64055 | 2'-Fluoro-2'-deoxyguanosine, 99% | 78842-13-4 | 1g | $117.65 | 2024-03-01 | Buy |
| TRC | D235125 | 2''-Deoxy-2''-fluoroguanosine | 78842-13-4 | 250mg | $140 | 2021-12-16 | Buy |
| Biosynth Carbosynth | ND02828 | 2'-Deoxy-2'-fluoroguanosine | 78842-13-4 | 2g | $170 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 56441 | 2??-Deoxy-2??-fluoroguanosine | 78842-13-4 | 500mg | $190 | 2021-12-16 | Buy |
2'-Deoxy-2'-fluoroguanosine Chemical Properties,Uses,Production
Uses
2''-Deoxy-2''-fluoroguanosine, can be used as powerful tool for structural manipulation of G-quadruplexes. It is also a influenza viral polymerase inhibitor like Ribavirin (R414475), used as a antiviral drug against avian (H5N1) influenza virus.
Definition
2'-Deoxy-2'-fluoroguanosine is an analog of guanosine that inhibits the viral life cycle. It is a competitive inhibitor of the viral transcriptase enzyme, which prevents RNA synthesis and subsequent protein synthesis. 2'-Deoxy-2'-fluoroguanosine has been shown to inhibit the growth of wild-type viruses in cell culture and to be effective against resistant mutants in cell culture. This drug has also been shown to inhibit the replication of herpes simplex virus type 1 (HSV-1) and influenza virus type A/WSN/33 (H1N1) in cell culture, as well as inhibiting the production of rna from these viruses.
Synthesis
The synthesis of 2'-deoxy-2'-fluoroguanosine was accomplished using tetraisopropyldisiloxanyl (TPDS) protected 9-beta-D-arabinofuranosylguanine as starting material, and conversion to the intermediate diisobutyryl-arabinofuranosylguanosine. Deprotection of the TPDS group, was followed by protection of the hydroxyl group with THP to give diisobutyryl di-THP protected arabinofuranosylguanine. Selective O-deacylation and triflation was followed by treatment of the crude product with fluoride, then deprotection of the THP groups.
2'-Deoxy-2'-fluoroguanosine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from 2'-Deoxy-2'-fluoroguanosine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-06 | 2'-Deoxy-2'-fluoroguanosine
78842-13-4
|
US $0.00-0.00 / KG | 1KG | 98% | 300KGS | Yunbio Tech Co.,Ltd. | |
 |
2023-05-12 | 2'-Deoxy-2'-fluoroguanosine
78842-13-4
|
US $0.00 / g | 100g | ≥98%(HPLC) | 20t | Hefei Huana Biomedical Technology Co.,Ltd. | |
 |
2023-04-04 | 2'-Deoxy-2'-fluoroguanosine
78842-13-4
|
US $0.00-0.00 / kg | 1kg | 98% | 500kg per month | Zhejiang Hengkang Pharmaceutical Co., Ltd. |
-
- 2'-Deoxy-2'-fluoroguanosine
78842-13-4
- US $0.00-0.00 / KG
- 98%
- Yunbio Tech Co.,Ltd.
-
- 2'-Deoxy-2'-fluoroguanosine
78842-13-4
- US $0.00 / g
- ≥98%(HPLC)
- Hefei Huana Biomedical Technology Co.,Ltd.
-
- 2'-Deoxy-2'-fluoroguanosine
78842-13-4
- US $0.00-0.00 / kg
- 98%
- Zhejiang Hengkang Pharmaceutical Co., Ltd.