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Acotiamide hydrochloride trihydrate

Acotiamide hydrochloride trihydrate structure

CAS No.: 773092-05-0

Chemical Name:: Acotiamide hydrochloride trihydrate

Synonyms: Acotiamide hydrochloride hydrate;Acotiamide HCl;Ym-443;Acotiae;Z-338 HCl;YM-443 HCl;Unii-nmw7447A9a;Acofide trihydrate;YM-443;ACOTIAMIDE HCL;Acotiamide trihydrate

CBNumber:: CB52493115

Molecular Formula:: C21H31ClN4O5S

Molecular Weight:: 487.013

MDL Number:: MFCD28101055

MOL File:: 773092-05-0.mol

MSDS File:: SDS

Last updated:2024-03-11 17:00:25

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Acotiamide hydrochloride trihydrate Properties

Melting point	193-195o C
storage temp.	2-8°C
solubility	Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) Methanol (Slightly)
form	Solid
color	Pale Yellow
FDA UNII	NMW7447A9A

Acotiamide hydrochloride trihydrate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A190240	AcofideTrihydrate	773092-05-0	1g	$210	2021-12-16	Buy
Biosynth Carbosynth	FA137643	Acotiamide HCl hydrate	773092-05-0	500mg	$230	2021-12-16	Buy
Biosynth Carbosynth	FA137643	Acotiamide HCl hydrate	773092-05-0	1g	$350	2021-12-16	Buy
Biosynth Carbosynth	FA137643	Acotiamide HCl hydrate	773092-05-0	2g	$440	2021-12-16	Buy
ChemScene	CS-0020306	Acotiamide(monohydrochloridetrihydrate) 99.28%	773092-05-0	100mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
A190240	1g	$210	Buy
FA137643	500mg	$230	Buy
FA137643	1g	$350	Buy
FA137643	2g	$440	Buy
CS-0020306	100mg	$50	Buy

Acotiamide hydrochloride trihydrate Chemical Properties,Uses,Production

Description

In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca²⁺-activated Cl^-current with an IC₅₀ of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K⁺ currents with an IC₅₀ of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.

Originator

Zeria Pharmaceutical (Japan)

Uses

Acofide Trihydrate is a gastrointestinal prokinectic agent used in the treatment of functional malnutrition. A tablet for the treatment of functional dyspepsia.

brand name

Acofide

Synthesis

Commercial 3,4,5-trimethoxybenzoic acid was first converted to the corresponding acid chloride, which was isolated by co-distillation with hexane. In refluxing dichloroethane (DCE), the acid chloride was coupled with the commercially available thiazole amine to give the desired amidothiazole in 89% yield. From this intermediate, amide linkage, selective demethylation of the 2-methoxy group, salt formation, and recrystallization were accomplished in the following sequence: the thiazole ester was reacted with N,N-diisopropyl ethylenediamine in DMA at elevated temperatures. Upon cooling, the mixture was dissolved in n-butanol and washed with aqueous sodium hydroxide. Subsequent treatment with HCl gas in isopropanol gave the corresponding HCl salt as crystals that could be collected by filtration. The product obtained was further crystallized from 4:1 isopropanol and water to give the desired product acotimide (I) as the hydrochloride trihydrate in 71% yield.

Synthesis_773092-05-0

Acotiamide hydrochloride trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Acotiamide hydrochloride trihydrate Suppliers

Global( 231)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Xinhao Biotechnology Co., Ltd	+86-18120578002 +86-18120578002	xinhao-6@xinhaoshengwu.com	China	350	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	17791478691	yklbiotech@163.com	CHINA	296	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58

Supplier	Advantage
Wuhan Xinhao Biotechnology Co., Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Shaanxi Yikanglong Biotechnology Co., Ltd.	58
Anhui Dexinjia Biopharm Co., Ltd	58

View Lastest Price from Acotiamide hydrochloride trihydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Ym-443 773092-05-0	US $10.00-100.00 / kg	1kg	99%	100 tons	Wuhan Xinhao Biotechnology Co., Ltd
2024-03-28	Acotiamide hydrochloride trihydrate 773092-05-0	US $0.00 / kg	25kg	≥99%	Inquiry	PNP Biotech Co. Ltd
2024-01-08	Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0 773092-05-0	US $1.00 / G	100G	99.9%	50000 tons	Wuhan Boyuan Import & Export Co., LTD

Ym-443
773092-05-0
US $10.00-100.00 / kg
99%
Wuhan Xinhao Biotechnology Co., Ltd

Acotiamide hydrochloride trihydrate
773092-05-0
US $0.00 / kg
≥99%
PNP Biotech Co. Ltd

Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0
773092-05-0
US $1.00 / G
99.9%
Wuhan Boyuan Import & Export Co., LTD

Acotiamide hydrochloride trihydrate Spectrum

Acotiamide hydrochloride trihydrate(773092-05-0)¹HNMR

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Aprepitant Acotiamide Hydrochloride Hydrate

1of3

N-(2-(Diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxyamide monohydrochloride trihydrate Unii-nmw7447A9a Ym-443 AcotiaMide hydrochloride trihydrate Acotiae 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3) Acofide trihydrate N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino] Acotiamide HCl Hydrate N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide monohydrochloride trihydrate Acotiamide HCl Trihydrate N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydro N-[2-[DI(PROPAN-2-YL)AMINO]ETHYL]-2-[(2-HYDROXY-4,5-DIMETHOXYBENZOYL)AMINO]-1,3-THIAZOLE-4-CARBOXAMIDE YM-443;ACOTIAMIDE HCL Acotamine hydrochloride trihydrate N-[2-(Diisopropylamino)ethyl]-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide Hydrochloride Trihydrate N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide,trihydrate,hydrochloride Acotiamide trihydrate AcotiaMide hydrochloride hydrate CAS 773092-05-0 Hot sale top quality Acotiamide hydrochloride hydrate with factory price High Quality Acotiamide hydrochloride hydrate Acotiamide hydrochloride hydrate Acotiamide HCl 773092-05-0 Bulk AcotiaMide hydrochloride hydrate CAS NO.773092-05-0 Acotiamide hydrochlorid Acorticoid hydrochloride N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate (1:1:3) YM-443 HCl Z-338 HCl Acetylformamide hydrochloride trihydrate Acofide trihydrate,Acotiamide hydrochloride trihydrate,Acotiamide hydrochloride hydrate Acotiamide hydrochloride trihydrate (YM443 TIANFUCHEM--773092-05-0--Ym-443 factory price Acotiamide hydrochloride hydrate Acotiamide HCl 4-((4-((2-(diisopropylamino)ethyl)carbamoyl)thiazol-2-yl)carbamoyl)-5-hydroxyphthalic acid hydrochloride trihydrate (Acotiamide HCl Trihydrate) 773092-05-0 C21H30N4O5SHCl3H2O C21H37ClN4O8S C21H31ClN4O5S C21H30N4O5SClH3H2O C21H30N4O5SClH Inhibitors API 773092-05-0