A-674563
- CAS No.
- 552325-73-2
- Chemical Name:
- A-674563
- Synonyms
- CS-258;A-674563;A-674563 /A674563;A-674563 USP/EP/BP;A-674563;A 674563; A674563;A-674563 Akt1 Inhibitor A-674563;(S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;(2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine;Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-;(alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine
- CBNumber:
- CB52561454
- Molecular Formula:
- C22H22N4O
- Molecular Weight:
- 358.44
- MDL Number:
- MFCD11840461
- MOL File:
- 552325-73-2.mol
| Boiling point | 624.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.229 |
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; ≥23.8 mg/mL in H2O; ≥4.9 mg/mL in DMSO |
| form | solid |
| pka | 13.43±0.40(Predicted) |
| FDA UNII | 3W2X0WGW6C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
A-674563 price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18715 | A-674563 ≥95% | 552325-73-2 | 500μg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 552325-73-2 | 1mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 552325-73-2 | 5mg | $333 | 2024-03-01 | Buy |
| Cayman Chemical | 18715 | A-674563 ≥95% | 552325-73-2 | 10mg | $570 | 2024-03-01 | Buy |
| Usbiological | 349624 | A-674563 | 552325-73-2 | 500ug | $265 | 2021-12-16 | Buy |
A-674563 Chemical Properties,Uses,Production
Uses
A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively.
Biological Activity
a-674563 is a potent and selective akt1 inhibitor with ic50 value of 14 nm. a-67453 also inhibited pka and cdk2 with ic50 value of 16 nm and 46 nm.akt, also known as protein kinase b, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.in miapaca-2 cells treated with a-674563 for 48 hour, it slowed the tumor cell proliferation (ec50 = 0.4 μm). in sts cells, phosphorylation of gsk3 and mdm2 was prominently reduced by a-674563 treatment. [1] akt inhibition-induced g2 cells cycle arrest and apoptosis were also observed in a563-treated sts cells. [2]in scid mice carrying established pc-3 tumors, administration of a-674563 at 40 mg/kg per day for 21 days, combined with administration of paclitaxel at 15 mg/kg per day on days 20.24.28, increased the efficacy of paclitaxel compared with paclitaxel monotherapy. [1] a563 also significantly blocked ht1080 xenograft growth in nude mice. [2]
target
Akt1
References
1. luo y, shoemaker ar, liu x et al. potent and selective inhibitors of akt kinases slow the progress of tumors in vivo. mol cancer ther. 2005 jun;4(6):977-86.2. zhu qs, ren w, korchin b et al. soft tissue sarcoma cells are highly sensitive to akt blockade: a role for p53-independent up-regulation of gadd45 alpha. cancer res. 2008 apr 15;68(8):2895-903.
A-674563 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28761 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
