2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
![2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Structure](CAS/GIF/852391-19-6.gif)
- CAS No.
- 852391-19-6
- Chemical Name:
- 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- Synonyms
- Necrostatin 2;Necroptotic Inhibitor;Necrostatin 2 R-isomer;MTH-DL-TRYPTOPHAN; NECROPTOTIC INHIBITOR;(5R)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)-
- CBNumber:
- CB52626148
- Molecular Formula:
- C13H12ClN3O2
- Molecular Weight:
- 277.71
- MDL Number:
- MOL File:
- 852391-19-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P260-P280-P301+P310 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11657 | Necrostatin-2 ≥98% | 852391-19-6 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 11657 | Necrostatin-2 ≥98% | 852391-19-6 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 11657 | Necrostatin-2 ≥98% | 852391-19-6 | 10mg | $223 | 2024-03-01 | Buy |
| ApexBio Technology | A3652 | Necrostatin2 | 852391-19-6 | 5mg | $273 | 2021-12-16 | Buy |
| AK Scientific | 6577CS | (5r)-5-[(7-Chloro-1h-Indol-3-Yl)methyl]-3-Methylimidazolidine-2,4-Dione | 852391-19-6 | 10mg | $345 | 2021-12-16 | Buy |
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties,Uses,Production
Biological Activity
necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro.
target
RIPK2
References
[1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40.
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |