AM-095
- CAS No.
- 1345614-59-6
- Chemical Name:
- AM-095
- Synonyms
- AM-095;AM095 sodium;AM095 >=98% (HPLC);AM095 (Sodium Salt);AM-095;AM095;AM 095;AM095 hydrochloride;LPL Receptor,AM095,inhibit,Lysophospholipid Receptor,Inhibitor,AM-095,AM 095;sodium,2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetate;(2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid) sodium salt;4'-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid sodium salt (1:1)
- CBNumber:
- CB52627312
- Molecular Formula:
- C27H25N2NaO5
- Molecular Weight:
- 480.5
- MDL Number:
- MFCD23380594
- MOL File:
- 1345614-59-6.mol
- MSDS File:
- SDS
AM-095 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3166 | AM095 | 1345614-59-6 | 5mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A3166 | AM095 | 1345614-59-6 | 10mM(in 1mL DMSO) | $115 | 2021-12-16 | Buy |
| ChemScene | CS-1118 | AM095 99.72% | 1345614-59-6 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A3166 | AM095 | 1345614-59-6 | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-1118 | AM095 99.72% | 1345614-59-6 | 10mg | $168 | 2021-12-16 | Buy |
AM-095 Chemical Properties,Uses,Production
Biological Activity
am095 is a novel, potent and orally bioavailable antagonist of lysophosphatidic acid type 1 receptor (lpa1) with ic50 values of 0.73 and 0.98 μm for mouse or recombinant human lpa1, respectively [1].
in vitro
am095 has shown to inhibit lpa1-induced chemotaxis of both mouse lpa1/cho cells and human a2058 melanoma cells with ic50 values of 0.78 μm and 0.23μm [1].
in vivo
am095 could dose-dependently block lpa-induced histamine release with an ed50 value of 8.3 mg/kg in mice. additionally, am095 has been revealed to remarkably reduce the balf collagen and protein with an ed50 value of 10 mg/kg in lungs. am095 has also shown to decrease both macrophage and lymphocyte infiltration induced by bleomycin in mice [1].
target
LPA1 receptor
References
[1] swaney js1, chapman c, correa ld, stebbins kj, broadhead ar, bain g, santini am, darlington j, king cd, baccei cs, lee c, parr ta, roppe jr, seiders tj, ziff j, prasit p, hutchinson jh, evans jf, lorrain ds. pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. j pharmacol exp ther. 2011 mar;336(3):693-700.
AM-095 Preparation Products And Raw materials
Raw materials
Preparation Products
AM-095 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |