Donepezil-d4 Hydrochloride
- CAS No.
- 1219798-88-5
- Chemical Name:
- Donepezil-d4 Hydrochloride
- Synonyms
- Isoflurane Impurity 11;Donepezil-d4 Hydrochloride;2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl-d2)-4-piperidinyl]methyl-d2]-1H-inden-1-one,monohydrochloride
- CBNumber:
- CB52670075
- Molecular Formula:
- C24H30ClNO3
- Molecular Weight:
- 415.96
- MDL Number:
- MFCD08704900
- MOL File:
- 1219798-88-5.mol
Donepezil-d4 Hydrochloride price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18251 | Donepezil-d4 (hydrochloride) ≥99% deuterated forms (d1-d4) | 1219798-88-5 | 500μg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 18251 | Donepezil-d4 (hydrochloride) ≥99% deuterated forms (d1-d4) | 1219798-88-5 | 1mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 18251 | Donepezil-d4 (hydrochloride) ≥99% deuterated forms (d1-d4) | 1219798-88-5 | 5mg | $721 | 2024-03-01 | Buy |
| Medical Isotopes, Inc. | D17086 | (+/-)-Donepezil-d4HCl(bis-methylene-d4) | 1219798-88-5 | 25mg | $890 | 2021-12-16 | Buy |
| AK Scientific | 2668EL | 2-[Dideuterio-[1-[dideuterio(phenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride | 1219798-88-5 | 1mg | $293 | 2021-12-16 | Buy |
Donepezil-d4 Hydrochloride Chemical Properties,Uses,Production
Biological Activity
Donepezil-d4 (hydrochloride) is intended for use as an internal standard for the quantification of donepezil by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.2,3
References
1.Mu?oz-Torrero, D.Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseCurr. Med. Chem.152433-2455(2008) 2.Ramalingayya, G.V., Nampoothiri, M., Nayak, P.G., et al.Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasksPharmacogn. Mag.12(Suppl 1)S63-S70(2016) 3.Shumizu, S., Mizuguchi, Y., Sobue, A., et al.Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in miceJ. Pharmacol. Sci.127(4)439-445(2015)
Donepezil-d4 Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Donepezil-d4 Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 8012 | 55 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4984 | 58 |
| Manhag Testing Technology Co., Ltd | 020-020-3846236 17688849268 | 2443244976@qq.com | China | 7775 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | 13670046396 | ORDERS@QCSRM.COM | China | 18820 | 58 |
| Yancheng Tongming Biotechnology Co., Ltd. | 15195160625 | 2863565288@qq.com | China | 5194 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5019 | 58 |