1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
- CAS No.
- 508186-14-9
- Chemical Name:
- 1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
- Synonyms
- Ac-COA Synthase Inhibitor;ACSS;MDK-6149;INVIVO-6149;Ac-CoA Synthase Inhibitor1;Acetyl-CoA Synthase Inhibitor;ACSS2 INHIBITOR;AC-COA SYNTHASE INHIBITOR;1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2...;Urea, N-(2,3-di-2-thienyl-6-quinoxalinyl)-N'-(2-methoxyethyl)-;1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea
- CBNumber:
- CB52748086
- Molecular Formula:
- C20H18N4O2S2
- Molecular Weight:
- 410.51
- MDL Number:
- MFCD03232237
- MOL File:
- 508186-14-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.33756 | Ac-CoA Synthase Inhibitor - CAS 508186-14-9 - Calbiochem | 508186-14-9 | 25MG | $223 | 2023-01-07 | Buy |
| ChemScene | CS-7715 | Ac-CoASynthaseInhibitor1 99.23% | 508186-14-9 | 25mg | $228 | 2021-12-16 | Buy |
| ChemScene | CS-7715 | Ac-CoASynthaseInhibitor1 99.23% | 508186-14-9 | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-7715 | Ac-CoASynthaseInhibitor1 99.23% | 508186-14-9 | 10mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-7715 | Ac-CoASynthaseInhibitor1 99.23% | 508186-14-9 | 50mg | $396 | 2021-12-16 | Buy |
1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea Chemical Properties,Uses,Production
Uses
Ac-CoA Synthase Inhibitor can be prepared for the treatment of Compositions for neurological and cognitive diseases and disorders, particularly useful in the treatment of anxiety disorders and disorders such as phobias, panic disorders, psychosocial stress (such as seen in disasters, disasters or victims of violence), obsessive-compulsive disorders, generalized Anxiety disorders and post-traumatic stress disorder (PTSD).Also it may be used to modulate long-term memory storage or consolidation, to treat addiction and/or addiction-related diseases or conditions, to prevent or treat acute alcohol-induced memory Deficits and chronic alcohol-induced memory deficits.
Biological Activity
Ac-CoA Synthase Inhibitor is a potent and specific inhibitor of acetyl-CoA synthase 2 (ACSS2). It also inhibits respiratory syncytial virus (RSV).
in vitro
Ac-CoA Synthase Inhibitor inhibits the incorporation of [14C]acetate into lipids in HepG2 cells with IC50 of 6.8 μM. It inhibits histone acetylation by [14C]acetate in HepG2 cells with IC50 of 5.5 μM.
target
| Target | Value |
| ACSS2 (Cell-free assay) | ~0.6 μM |
1-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 18088 | 64 |