4-HYDROXYISOLEUCINE
- CAS No.
- 55399-93-4
- Chemical Name:
- 4-HYDROXYISOLEUCINE
- Synonyms
- HIL;HYDROXYISOLEUCINE, 4-;4 -Hydroxyisoleucic acid;HYDROXYISOLEUCINE, 4-(FG);(4S)-4-Hydroxy-L-isoleucine;Hydroxyisoleucine 55399-93-4;TIANFU-CHEM 4-HYDROXYISOLEUCINE;4-HYDROXYISOLEUCINECAS:55399-93-4;[DISCONTINUED] Replaced by KIT-00008502-0HK;4-HYDROXYISOLEUCINE; 4-HYDROXY-L-ISOLEUCINE
- CBNumber:
- CB5274835
- Molecular Formula:
- C6H13NO3
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD07357252
- MOL File:
- 55399-93-4.mol
- MSDS File:
- SDS
| Melting point | 223-224℃ |
|---|---|
| Boiling point | 331.6±32.0 °C(Predicted) |
| Density | 1.181±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 147℃ |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 2.41±0.25(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D +32.5±2.0°, c = 1 in H2O |
| BRN | 4128096 |
| InChI | InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1 |
| InChIKey | OSCCDBFHNMXNME-YUPRTTJUSA-N |
| SMILES | C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O |
| FDA UNII | 4SWT01T54O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
4-HYDROXYISOLEUCINE price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 50118 | (4S)-4-Hydroxy-L-isoleucine from fenugreek seed, ≥98.0% (TLC) | 55399-93-4 | 50mg | $527 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 25mg | $1169 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 11812 | 4-Hydroxyisoleucine | 55399-93-4 | 10mg | $535 | 2024-03-01 | Buy |
4-HYDROXYISOLEUCINE Chemical Properties,Uses,Production
Description
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM. In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
Occurrence
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
Uses
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
Definition
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
Biological Activity
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
4-HYDROXYISOLEUCINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChiRial Biomaterial Co Ltd | +8619951673840 | cero.xia@chirial.com | China | 156 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15933 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
View Lastest Price from 4-HYDROXYISOLEUCINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-06 | 4-HYDROXYISOLEUCINE
55399-93-4
|
US $40.00-30.00 / kg | 1kg | 99% | 30 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-04-18 | 4-hydroxyisoleucine
55399-93-4
|
US $0.00-0.00 / g | 1g | 97% | 10 tons | ChiRial Biomaterial Co Ltd | |
 |
2022-09-30 | 4-HYDROXYISOLEUCINE
55399-93-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4-HYDROXYISOLEUCINE
55399-93-4
- US $40.00-30.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
-
- 4-hydroxyisoleucine
55399-93-4
- US $0.00-0.00 / g
- 97%
- ChiRial Biomaterial Co Ltd
-
- 4-HYDROXYISOLEUCINE
55399-93-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.