KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
- CAS No.
- 58002-62-3
- Chemical Name:
- KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
- Synonyms
- KAINIC ACID MONOHYDRATE;KAINIC ACID HYDRATE;(?)-(α)-Kainic Acid hydrate;(-)-KAINIC ACID, MONOHYDRATE;(-)-α-Kainic Acid Monohydrate;(-)-(α)-Kainic Acid (hydrate);KAINIC ACID MONOHYDRATE, ISOLATED FROM D;kainic acid monohydrate from digenea simplex;2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE;(2S,3S,4S)-2-CARBOXY-4-ISOPROPENYL-3-PYRROLIDINEACETIC ACID
- CBNumber:
- CB5351307
- Molecular Formula:
- C10H17NO5
- Molecular Weight:
- 231.25
- MDL Number:
- MFCD00150833
- MOL File:
- 58002-62-3.mol
| Melting point | 250-252°C |
|---|---|
| RTECS | UX9665250 |
| storage temp. | 2-8°C |
| solubility | H2O: >10 mg/mL |
| form | solid |
| color | white |
| Sensitive | Light Sensitive |
| FDA UNII | I519JC63XY |
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K0250 | Kainic acid monohydrate ≥99% (TLC) | 58002-62-3 | 10mg | $261 | 2024-03-01 | Buy |
| Sigma-Aldrich | K0250 | Kainic acid monohydrate ≥99% (TLC) | 58002-62-3 | 50mg | $1150 | 2024-03-01 | Buy |
| Alfa Aesar | J66590 | Kainic acid monohydrate, 98% | 58002-62-3 | 10mg | $177 | 2023-06-20 | Buy |
| Cayman Chemical | 78050 | (-)-(α)-Kainic Acid (hydrate) ≥98% | 58002-62-3 | 5mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 78050 | (-)-(α)-Kainic Acid (hydrate) ≥98% | 58002-62-3 | 10mg | $135 | 2024-03-01 | Buy |
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Chemical Properties,Uses,Production
Description
(−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities. It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively). (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes. It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 μM. Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal. It has been commonly used to induce seizures in rodents.
Uses
Kainic acid monohydrate has been used:
- As a convulsant to induce epileptogenesis and epilepsy in mice.
- To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
- To induce seizures in rat model.
- To induce status epilepticus in adult male Wistar rats.
Uses
Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.
General Description
Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.
Biochem/physiol Actions
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9320 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4850 | 55 |
View Lastest Price from KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
58002-62-3
|
US $1.00 / kg | 1kg | 95%-99% | 1000kg | Career Henan Chemical Co |
-
- KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE
58002-62-3
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co