ChemicalBook >> CAS DataBase List >>15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE structure

CAS No.: 2623-22-5

Chemical Name:: 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

Synonyms: 15-mas;NSC-267030;deacetylanguidin;Desacetylanguidine;15-ACETOXYSCIRPENOL;monoacetoxyscirpenol;15-ACETOXYSCIRPENDIOL;15-MONOACETYLSCIRPENOL;15-MONOACETOXYSCIRPENOL;12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate

CBNumber:: CB5379697

Molecular Formula:: C17H24O6

Molecular Weight:: 324.37

MDL Number:: MFCD32205816

MOL File:: 2623-22-5.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:00

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15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Properties

Melting point	170-172 °C
Boiling point	465.5±45.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	≤10mg/ml in methanol;10mg/ml in dichloromethane
form	powder
pka	13.72±0.70(Predicted)
FDA UNII	Z9XD0SRM7U

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310-P261-P280

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

YD0111000

HazardClass

6.1(a)

PackingGroup

HS Code

29329990

NFPA 704

	0
2		0

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11431	15-acetoxy Scirpenol ≥98%	2623-22-5	1mg	$242	2024-03-01	Buy
Cayman Chemical	11431	15-acetoxy Scirpenol ≥98%	2623-22-5	5mg	$965	2024-03-01	Buy
Usbiological	412029	15-Acetoxyscirpenol	2623-22-5	1mg	$885	2021-12-16	Buy
TRC	A164293	15-Acetoxyscirpenol	2623-22-5	10mg	$4070	2021-12-16	Buy
ApexBio Technology	C4698	15-acetoxyScirpenol	2623-22-5	5mg	$1104	2021-12-16	Buy

Product number	Packaging	Price	Buy
11431	1mg	$242	Buy
11431	5mg	$965	Buy
412029	1mg	$885	Buy
A164293	10mg	$4070	Buy
C4698	5mg	$1104	Buy

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer.

Hazard

A poison by ingestion. A mild skin irritant.

Biological Activity

15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2].

References

[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654.

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE synthesis

Synthesis of 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE from DIACETOXYSCIRPENOL

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Preparation Products And Raw materials

Raw materials

scirpentriol DIACETOXYSCIRPENOL

Preparation Products

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Shanghai Aladdin Bio-Chem Technology Co.,LTD	18521735133 18521732826;	market@aladdin-e.com	China	25015	65

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
BOC Sciences	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
J & K SCIENTIFIC LTD.	76
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65

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deacetylanguidin monoacetoxyscirpenol 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE 15-ACETOXYSCIRPENDIOL 15-ACETOXYSCIRPENOL (3-alpha)-12,13-epoxytrichothec-9-ene-3,4,15-triol15-acetate 15-mas 4-beta,15-triol,12,13-epoxy-trichothec-9-ene-3-alph15-acetate 15-acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene 15-MONOACETYLSCIRPENOL 15-MONOACETOXYSCIRPENOL 15-Acetoxyscirpendiol, 15-Acetoxy-3α,4β-dihydroxy-12,13-epoxytrichothec-9-ene 12,13-Epoxytrichothec-9-ene-3α,4β,15-triol 15-acetate 3α,4β-Dihydroxy-15-acetoxy-12,13-epoxytrichotheca-9-ene NSC-267030 Anguidine, desacetyl(15-acetoxyscirpene-3,4-diol-bl5732) Desacetylanguidine Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3.alpha.,4.beta.)- Trichothec-9-ene-3.alpha.,4.beta.,15-triol, 12,13-epoxy-, 15-acetate 15 Acetoxyscirpenol (3alpha,4beta)-12,13-epoxy-trichothec-9-ene-3,4,15-triol 15-acetate ((2R,2S,3R,5R,5AR,9aR)-3-hydroxy-5,8-dimethyl-2,3,4,5,5a,6,7,9a-octahydrospiro[2,5-methanobenzo[b]oxepine-10,2-oxiran]-5a-yl)methyl acetate Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 15-acetate, (3α,4β)- Trichothec-9-ene-3.α.,4.β.,15-triol, 12,13-epoxy-, 15-acetate ((2S,2'R,3'R,5'R,5a'R,9a'R)-3'-Hydroxy-5',8'-dimethyl-2',3',4',5',7',9a'-hexahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-5a'(6'H)-yl)methyl acetate 2623-22-5