DIBENZEPINE HCL
- CAS No.
- 315-80-0
- Chemical Name:
- DIBENZEPINE HCL
- Synonyms
- ecatril;noveril;neodalit;Ansiopax;)diazepin;Dibenzepine;DIBENZEPINE HCL;dibenzepinhydrochloride;hydrofluoride-1927wander;dibenzepinehydrochloride
- CBNumber:
- CB5437847
- Molecular Formula:
- C18H22ClN3O
- Molecular Weight:
- 331.84
- MDL Number:
- MFCD00798249
- MOL File:
- 315-80-0.mol
| Melting point | 238° |
|---|---|
| pka | 8.25(at 25℃) |
| FDA UNII | JLN0273S4Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H332-H301-H412 |
| Precautionary statements | P261-P271-P304+P340-P312-P273-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| RIDADR | 3249 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 orally in mice: 215 mg/kg (Hunziker) |
DIBENZEPINE HCL Chemical Properties,Uses,Production
Originator
Noveril ,Wander,Switz.,1965
Uses
Antidepressant.
Definition
ChEBI: Dibenzepin hydrochloride is a dibenzodiazepine.
Manufacturing Process
4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane.
After adding a concentrated benzenic solution of β-dimethylamino-ethyl
chloride freshly prepared from 3.75 grams of the hydrochloride with
concentrated sodium hydroxide solution, taking up in benzene and drying the
solution with potash, the mixture was boiled for 16 hours under reflux,
whereupon the reaction mixture was concentrated to dryness and the residue
distributed between ether and water. By exhaustive extraction of the basic
fractions with dilute acetic acid, precipitation with ammonia, taking up the
base in ether and working up the ethereal solution, there was obtained 5.05
grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11-
dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous
yellowish resin with the boiling point 185°C/0.01mm Hg. The base was
crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of
the monohydrochloride (from ethanol-ether) 234°-240°C.
brand name
Deprex;Ecatrol;Hf 1927;Neodit;Victoril.
Therapeutic Function
Psychostimulant
World Health Organization (WHO)
Dibenzepin hydrochloride, a tricyclic antidepressant, was introduced in 1968 for the treatment of depressive illness. By 1973 its use in Sweden had been associated with an unexpectedly high number of suicide attempts which led to its withdrawal in that country. Although its use has lapsed in several countries, it remains available in at least eight European countries.
DIBENZEPINE HCL Preparation Products And Raw materials
DIBENZEPINE HCL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| GIHI CHEMICALS CO.,LTD | 0086-571-86217390 | Sales@gihichem.com | China | 861 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Target molecule Corp. | 857-239-0968 | service1@targetmol.com | United States | 2559 | 60 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9916 | 58 |