ACETYL-DL-CARNITINE HYDROCHLORIDE
- CAS No.
- 2504-11-2
- Chemical Name:
- ACETYL-DL-CARNITINE HYDROCHLORIDE
- Synonyms
- TIMTEC-BB SBB003214;Acetyl-DL-carnitineHCl;acetyldl-carnitinechloride;d,l-acetylcarnitin-chlorid;(+/-)-ACETYLCARNITINE CHLORIDE;ACETYL-DL-CARNITINE HYDROCHLORIDE;acetyl-dl-carnitine hcl crystalline;Acetyl-DL-carnitinehydrochloridecrystalline;(RS)-3-Acetoxy-4-(trimetylammino)butyrate hydrochloride;(2-acetyloxy-3-carboxypropyl)-trimethylazanium,chloride
- CBNumber:
- CB5440058
- Molecular Formula:
- C9H18ClNO4
- Molecular Weight:
- 239.7
- MDL Number:
- MFCD00080826
- MOL File:
- 2504-11-2.mol
Melting point | 181 - 183°C |
---|---|
storage temp. | -20°C |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble to 100 mM in water |
Stability | Hygroscopic |
CAS DataBase Reference | 2504-11-2(CAS DataBase Reference) |
FDA UNII | 2WQN168TM5 |
ACETYL-DL-CARNITINE HYDROCHLORIDE price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A1509 | Acetyl-DL-carnitine hydrochloride | 2504-11-2 | 250mg | $165 | 2024-03-01 | Buy |
Sigma-Aldrich | A1509 | Acetyl-DL-carnitine hydrochloride | 2504-11-2 | 1g | $469 | 2024-03-01 | Buy |
TRC | A172003 | (±)-AcetylcarnitineChloride | 2504-11-2 | 100mg | $180 | 2021-12-16 | Buy |
TRC | A172003 | (±)-AcetylcarnitineChloride | 2504-11-2 | 10mg | $45 | 2021-12-16 | Buy |
ApexBio Technology | B6273 | (±)-Acetylcarnitinechloride | 2504-11-2 | 100mg | $125 | 2021-12-16 | Buy |
ACETYL-DL-CARNITINE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biological Activity
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
Purification Methods
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]
ACETYL-DL-CARNITINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ACETYL-DL-CARNITINE HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
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