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ChemicalBook >> CAS DataBase List >>(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Structure
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST structure
CAS No.
5652-28-8
Chemical Name:
(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
Synonyms
2-AP3;Alanine, 3-phosphono-;2-Amino-3-phosphonopropionic acid;(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
CBNumber:
CB5503036
Molecular Formula:
C3H8NO5P
Molecular Weight:
169.07
MDL Number:
MFCD00014350
MOL File:
5652-28-8.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:09
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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Properties

Boiling point 481.6±55.0 °C(Predicted)
Density 1.763±0.06 g/cm3(Predicted)
solubility PBS (pH 7.2): 2 mg/ml
form White powder.
pka 1.22±0.10(Predicted)
FDA UNII 0H89G8110O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
HS Code  2931499090
NFPA 704
0
2 0

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13852 DL-AP3 ≥95% 5652-28-8 50mg $37 2024-03-01 Buy
Cayman Chemical 13852 DL-AP3 ≥95% 5652-28-8 100mg $68 2024-03-01 Buy
TRC A627553 DL-2-Amino-3-phosphonopropionicAcid(AP3) 5652-28-8 100mg $75 2021-12-16 Buy
TRC A627553 DL-2-Amino-3-phosphonopropionicAcid(AP3) 5652-28-8 250mg $160 2021-12-16 Buy
Medical Isotopes, Inc. 38685 DL-2-Amino-3-phosphonopropionic acid 5652-28-8 250mg $650 2021-12-16 Buy
Product number Packaging Price Buy
13852 50mg $37 Buy
13852 100mg $68 Buy
A627553 100mg $75 Buy
A627553 250mg $160 Buy
38685 250mg $650 Buy

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Chemical Properties,Uses,Production

Description

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.

Uses

DL-2-Amino-3-phosphonopropionic acid (AP3) is an inhibitor of phosphoserine phosphatase and mGluR. Also known as the antagonist of a receptor that is coupled to phosphoinositide metabolism in brain slices. D,L-2-Amino-3-phosphonopropionic acid is also an inhibitor of metabotropic glutamate receptors in rat brain.

Definition

ChEBI: 2-amino-3-phosphonopropanoic acid is a non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It has a role as a metabotropic glutamate receptor antagonist and a human metabolite. It is a non-proteinogenic alpha-amino acid, a member of phosphonic acids and an alanine derivative.

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Preparation Products And Raw materials

Raw materials

Preparation Products

(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST Suppliers

Global( 17)Suppliers
Supplier Tel Email Country ProdList Advantage
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39997 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 9729 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29803 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 18621169109 market03@meryer.com China 27996 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2488 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Supplier Advantage
Nextpeptide Inc 		58
Aladdin Scientific 		58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Henan Alpha Chemical Co., Ltd. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 58
Shanghai Tachizaki Biomedical Research Center 58
Nantong QuanYi Biotechnology Co., Ltd 58

5652-28-8((+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST)Related Search:

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(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST 2-Amino-3-phosphonopropionic acid 2-AP3 Alanine, 3-phosphono- 5652-28-8