BAY 36-7620
- CAS No.
- 232605-26-4
- Chemical Name:
- BAY 36-7620
- Synonyms
- BAY 36-7620;(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one;1H-Cyclopenta[c]furan-1-one, hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-, (3aS,6aS)-;(3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one
- CBNumber:
- CB5838370
- Molecular Formula:
- C19H18O2
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD03700725
- MOL File:
- 232605-26-4.mol
Boiling point | 471.9±34.0 °C(Predicted) |
---|---|
Density | 1.19±0.1 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | <27.84mg/ml in ethanol; <27.84mg/ml in DMSO |
form | solid |
color | White |
FDA UNII | 0P934RSF8B |
BAY 36-7620 price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 2501 | Bay36-7620 ≥98%(HPLC) | 232605-26-4 | 10 | $252 | 2021-12-16 | Buy |
TRC | B119003 | Bay36-7620 | 232605-26-4 | 2.5mg | $360 | 2021-12-16 | Buy |
ApexBio Technology | B5309 | Bay36-7620 | 232605-26-4 | 10mg | $377 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | BIO0000358 | BAY 36-7620 95.00% | 232605-26-4 | 10MG | $750.7 | 2021-12-16 | Buy |
BAY 36-7620 Chemical Properties,Uses,Production
Uses
Bay 36-7620, is an inhibitor of metabotropic glutamate receptor 1 (mGlu1 receptor), and thus suppresses tumor growth and angiogenesis in experimental non-small cell lung cancer (NSCLC).
Biological Activity
Selective mGlu 1 receptor non-competitive antagonist (IC 50 = 0.16 μ M) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.
in vitro
bay36-7620 is a potent and selective antagonist at mglu1receptors and inhibits >60% of mglu1a receptor constitutive activity (ic50 = 0.38 μm). bay36-7620 is thus the first described mglu1 receptor inverse agonist. moreover, bay36-7620 did not displace the [3h]quisqualate binding from the glu-binding pocket, indicating that bay36-7620 is a noncompetitive mglu1 antagonist [2].
in vivo
bay 36-7620 protected against pentylenetetrazole-induced convulsions in the mouse. as assessed in rats, bay 36-7620 was devoid of the typical side effects of the ionotropic glutamate (iglu) receptor antagonists phencyclidine and mk-801. therefore, bay 36-7620 did not disrupt sensorimotor gating, induce phencyclidine-like discriminative effects or stereotypical behavior, or facilitate intracranial self-stimulated behavior [3].
storage
Store at +4°C
References
[1] carroll fy, stolle a, beart pm, voerste a, brabet i, mauler f, joly c, antonicek h, bockaert j, müller t, pin jp, prézeau l. bay36-7620: a potent non-competitive mglu1 receptor antagonist with inverse agonist activity. mol pharmacol. 2001 may;59(5):965-73.
[2] de vry j, horváth e, schreiber r. neuroprotective and behavioral effects of the selective metabotropic glutamate mglu(1) receptor antagonist bay 36-7620. eur j pharmacol. 2001 oct 5;428(2):203-14.
BAY 36-7620 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 36-7620 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11732 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4209 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |