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Latanoprost (free acid)-d4

Latanoprost (free acid)-d4 Structure
Latanoprost (free acid)-d4 structure
CAS No.
1224443-47-3
Chemical Name:
Latanoprost (free acid)-d4
Synonyms
Latanoprost Acid-d4;[2H4]-Latanoprost Acid;Latanoprost (free acid)-d4;HNPFPERDNWXAGS-GPPKKVIBSA-N;Latanoprost EP Impurity H-d4 (Latanoprost USP Related Compound E-d4)
CBNumber:
CB62591551
Molecular Formula:
C23H30D4O5
Molecular Weight:
394.537707112
MDL Number:
MOL File:
1224443-47-3.mol
Last updated:2023-06-08 09:03:09
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Latanoprost (free acid)-d4 Properties

storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Oil to Gel
color Colorless.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

Latanoprost (free acid)-d4 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 316811 Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4) 1224443-47-3 50μg $44 2024-03-01 Buy
Cayman Chemical 316811 Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4) 1224443-47-3 100μg $84 2024-03-01 Buy
Cayman Chemical 316811 Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4) 1224443-47-3 500μg $341 2024-03-01 Buy
Cayman Chemical 316811 Latanoprost (free acid)-d4 ≥99% deuterated forms (d1-d4) 1224443-47-3 1mg $603 2024-03-01 Buy
TRC L177312 LatanoprostAcid-d4 1224443-47-3 10mg $1940 2021-12-16 Buy
Product number Packaging Price Buy
316811 50μg $44 Buy
316811 100μg $84 Buy
316811 500μg $341 Buy
316811 1mg $603 Buy
L177312 10mg $1940 Buy

Latanoprost (free acid)-d4 Chemical Properties,Uses,Production

Description

Latanoprost (free acid)-d4 (Lat-FA-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. It is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC50 value of 3.6 nM for human FP receptors, which is twice the potency of PGF2α and more than 200 times more potent latanoprost. The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid. However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.

Uses

Latanoprost Acid-d4 is the labeled analogue of Latanoprost Acid (L177310), a metabolite of Latanoprost. Latanoprost Acid (L177310) is a potent, selective FP prostanoid receptor agonist, a F-series Prostaglandin analog and is 200 times as potent as isopropyl ester form.

Definition

ChEBI: Latanoprost (free acid)-d4 is a prostanoid.

Latanoprost (free acid)-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

Latanoprost (free acid)-d4 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 18162595016 3287908757@qq.com China 9887 58
Henan Vcommend Consultrading Co., Ltd. 13393721940 sales@vcommend.com China 9886 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 58
Henan Vcommend Consultrading Co., Ltd. 58
Latanoprost (free acid)-d4 HNPFPERDNWXAGS-GPPKKVIBSA-N Latanoprost Acid-d4 [2H4]-Latanoprost Acid Latanoprost EP Impurity H-d4 (Latanoprost USP Related Compound E-d4) 1224443-47-3