ChemicalBook >> CAS DataBase List >>CHF 5074
CHF 5074
- CAS No.
- 749269-83-8
- Chemical Name:
- CHF 5074
- Synonyms
- GHF-5074;CHF 5074;CSP-1103;Itanapraced;Itanapraced (CHF5074);1-(3',4'-Dichloro-2-fluoro-4-biphenylyl)cyclopropanecarboxyl...;1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic Acid;1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-;1-(3',4'-Dichloro-2-fluoro-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid
- CBNumber:
- CB62627687
- Molecular Formula:
- C16H11Cl2FO2
- Molecular Weight:
- 325.16
- MDL Number:
- MFCD18633206
- MOL File:
- 749269-83-8.mol
Last updated:2023-06-08 09:02:59
| Boiling point | 466.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.467±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO:59.0(Max Conc. mg/mL);181.45(Max Conc. mM) |
| form | A solid |
| pka | 2.30±0.20(Predicted) |
| FDA UNII | C35RF1MWQZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H320-H335 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| NFPA 704 |
|
CHF 5074 price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27917 | CHF5074 | 749269-83-8 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 27917 | CHF5074 | 749269-83-8 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 27917 | CHF5074 | 749269-83-8 | 5mg | $151 | 2024-03-01 | Buy |
| ChemScene | CS-5022 | Itanapraced >98.0% | 749269-83-8 | 10mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-5022 | Itanapraced >98.0% | 749269-83-8 | 5mg | $110 | 2021-12-16 | Buy |
CHF 5074 Chemical Properties,Uses,Production
Biological Activity
Itanapraced (CHF 5074, CSP-1103) is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. It inhibits COX1 and COX2 with IC50 greater than 100 μM.
in vitro
In glioma cells expressing APPswe (H4swe), CHF5074 reduces Aβ42 release with IC50 of 3.6 μM. It had no inhibitory activity against COX-1 and COX-2 at concentrations up to 100 μM and 300 μM.
in vivo
In rats, CHF5074 is well absorbed orally (50%) and is slowly eliminated from plasma (half-life approximately 20 hours). In Tg2576 transgenic mice, chronic treatment of CHF5074 significantly reduced the total amount of Aβ in the brain, and at the histological level, no Notch-mediated toxic effects were found.
target
| Target | Value | ||||
| γ secretase () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7433 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Zhengzhou Jingjiang Chemical Co. LTD | 15238060619 | liucunjiang_11@163.com | China | 28 | 58 |
CHF 5074
GHF-5074
1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid GHF-5074
1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid
1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic Acid
Itanapraced
CSP-1103
Cyclopropanecarboxylic acid, 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-
1-(3',4'-Dichloro-2-fluoro-4-biphenylyl)cyclopropanecarboxyl...
Itanapraced (CHF5074)
Itanapraced,Inhibitor,CSP 1103,CHF-5074,Gamma secretase,γ-secretase,CHF 5074,CSP1103,inhibit
1-(3',4'-Dichloro-2-fluoro-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid
749269-83-8
749269-84-8
C16H11Cl2FO2
Inhibitors