(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
![(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Structure](CAS/20150408/GIF/727382-14-1.gif)
- CAS No.
- 727382-14-1
- Chemical Name:
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
- Synonyms
- 2,4-Dichlorobenzyl Alcohol Impurity 38;(3S) -4-chloro-3- [(trimethylsilyl) oxy] nitrile;(S)-4-chloro-3-((trimethylsilyl)oxy)butanenitrile;(S)-4-Chloro-3-(trimethylsilanyloxy)butyronitrile;(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile;Butanenitrile, 4-chloro-3-[(trimethylsilyl)oxy]-, (3S)-
- CBNumber:
- CB62694490
- Molecular Formula:
- C7H14ClNOSi
- Molecular Weight:
- 191.73
- MDL Number:
- MFCD30537510
- MOL File:
- 727382-14-1.mol
| Boiling point | 233.8±20.0 °C(Predicted) |
|---|---|
| Density | 1.002±0.06 g/cm3(Predicted) |
| form | liquid |
| color | light yellow |
| InChI | InChI=1S/C7H14ClNOSi/c1-11(2,3)10-7(6-8)4-5-9/h7H,4,6H2,1-3H3/t7-/m0/s1 |
| InChIKey | FLYSOKSACGLOAO-ZETCQYMHSA-N |
| SMILES | C(#N)C[C@H](O[Si](C)(C)C)CCl |
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile price
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Chemical Properties,Uses,Production
Description
(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile, also known as (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile, is a useful research compound. Its molecular formula is C7H14ClNOSi and its molecular weight is 191.73 g/mol. The purity is usually 95%.
Uses
(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile is used in the synthesis of statins or HMG-CoA reductase inhibitors.
Synthesis
The synthesis of (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile is as follows:
To a solution of (S)-4-chloro-3-hydroxy butanenitrile (52.5 g) in THF (150 mL) was added trimethyl silyl chloride (57.2 g) under inert atmosphere at 25 °C. The resulting reaction mixture was stirred for 10 min at 20°C. A solution of triethyl amine (53.4 g) in THF (100 mL) was added to above reaction mixture by maintaining reaction temperature below 40 °C. To the resulting reaction mixture catalytic amount of sodium iodide was added and stirred further for 5 h at 40°C. Reaction was monitored on GC as well TLC for complete conversion of starting material. After cooling to 0 °C, a 21% aqueous solution of sodium chloride (500 mL) was added and extracted with ethyl acetate (2 X 300 mL). Combined organic layer was dried with anhydrous sodium sulphate, filtered and concentrated under reduced pressure to obtain (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile as light brown liquid (84.0 g, 99%).![synthesis of (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile.png](/NewsImg/2022-12-01/6380548217412583178427824.jpg "synthesis of (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile.png")
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Jiangxi Sunway Chemical Co., Ltd. | +86-0794-5259909 +8615888611133 | dave@jxswchem.com | China | 22 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12722 | 58 |
| Hebei Henghe Import and Export Trading Co. LTD | +8618032935937 18032916000 | demi@hbtycoon.com | CHINA | 449 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 6709 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +8618958038633 | tony@sdhypharma.com | China | 61 | 58 |
View Lastest Price from (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile pictures](/ProductImageEN/2023-09/Small/f839b81b-4a1c-486a-85d5-1d220867bafe.jpg) |
2023-09-08 | (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
727382-14-1
|
US $30.00 / kg | 1kg | 99% | 20 tons | Anhui Ruihan Technology Co., Ltd | |
![(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile pictures](/ProductImageEN/2020-12/Small/428bcfc5-f312-4fcd-85f2-e403b9a8455a.jpg) |
2020-12-13 | (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
727382-14-1
|
US $10.00 / KG | 100KG | 99% | 100 | Hebei Henghe Import and Export Trading Co. LTD |
-
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
727382-14-1
- US $30.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
727382-14-1
- US $10.00 / KG
- 99%
- Hebei Henghe Import and Export Trading Co. LTD