ChemicalBook >> CAS DataBase List >>8-OXO-2'-DEOXYGUANOSINE
8-OXO-2'-DEOXYGUANOSINE
- CAS No.
- 88847-89-6
- Chemical Name:
- 8-OXO-2'-DEOXYGUANOSINE
- Synonyms
- 8-hydroxydeoxyguanosine;8-Hydroxy-dG;-deoxyguanosine;8-Hydroxy-2'-dG;8-Oxodeoxyguanosine;2-Amino-9-((2R,4S,5R);-3H-purine-6,8(7H,9H);2'-Deoxy-8-oxoguanosine;8-OXO-2'-DEOXYGUANOSINE;8-oxo-2'-deoxyGuanosine
- CBNumber:
- CB6269667
- Molecular Formula:
- C10H13N5O5
- Molecular Weight:
- 283.24
- MDL Number:
- MFCD00210311
- MOL File:
- 88847-89-6.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:04
| Melting point | 217-220°C |
|---|---|
| Density | 2.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 7.86±0.20(Predicted) |
| form | White to off-white solid. |
| color | Off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| FDA UNII | 4RGB38T3IB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | MF8782675 |
| HS Code | 29349990 |
8-OXO-2'-DEOXYGUANOSINE price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H5653 | 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) | 88847-89-6 | 1mg | $90.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | H5653 | 8-Hydroxy-2′-deoxyguanosine ≥98% (TLC) | 88847-89-6 | 5mg | $312 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 89320 | 8-Hydroxy-2'-deoxyguanosine ≥98% | 88847-89-6 | 10mg | $363 | 2024-03-01 | Buy |
8-OXO-2'-DEOXYGUANOSINE Chemical Properties,Uses,Production
Description
8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3
Chemical Properties
White Crystalline Solid
Uses
8-Hydroxy-2′-deoxyguanosine has been used:
- as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
- as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
- as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
- as a standard for LC/MS/MS analysis
Uses
A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.
Definition
ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.
Biochem/physiol Actions
A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis
References
1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41
8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 110)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
View Lastest Price from 8-OXO-2'-DEOXYGUANOSINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-27 | 8-OXO-2'-DEOXYGUANOSINE
88847-89-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 8-OXO-2'-DEOXYGUANOSINE
88847-89-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
88847-89-6(8-OXO-2'-DEOXYGUANOSINE)Related Search:
7-propyl-8-oxoguanosine
8-HYDROXYGUANOSINE
5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-8-OXO-2'-DEOXYGUANOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE
8-ALLYLOXY-3'-O-[(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINO]-5'-O-(4,4'-DIMETHOXYTRITYL)-N2-[(DIMETHYLAMINO)METHYLIDINE]-2'-DEOXYGUANOSINE
8-ALLYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE
1of4
8-HYDROXY-2'-DEOXYGUANOSINE
2'-Deoxy-8-oxoguanosine
7,8-Dihydro-8-oxo-2'-deoxyguanosine
8-Oxo-7,8-dihydro-2'-deoxyguanosine
8-Oxo-7,8-dihydrodeoxyguanosine
2'-Deoxy-8-oxo-D-guanosine
8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG
2'-Deoxy-8-hydroxyguanosine
8-Oxodeoxyguanosine
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,7-dihydropurine-6,8-quinone
2-azanyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
8-Hydroxy-2′-deoxyguanosine,8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
8-Hydroxy-2'-deoxyguanosineDiscontinued See O850250
2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione
Guanosine,2'-deoxy-7,8-dihydro-8-oxo-
7,8-dihydro-2’-deoxy-8-oxo-guanosin
2-Amino-9-((2R,4S,5R)
-3H-purine-6,8(7H,9H)
7,8-dihydro-2’-deoxy-8-oxoguanosine
8-oxo-7-hydrodeoxyguanosine
8-OXO-2'-DEOXYGUANOSINE
8-Oxo-2'-deoxyguanosine (8-Oxo-dG)
8-Hydroxy-desoxyguanosine
Mouse 8-Hydroxy-desoxyguanosine elisa kit
8-OXO-2'-DEOXYGUANOSINE USP/EP/BP
-deoxyguanosine
8-Hydroxy-2'-dG
8-hydroxydeoxyguanosine
8-Hydroxy-dG
8-HYDROXY-2'-DEOXYGUANOSINE UNLABELED 25 UG/ML IN WATER
Inhibitor,8Hydroxy2'deoxyguanosine,inhibit,Endogenous Metabolite,8 Hydroxy 2' deoxyguanosine
*Carisoprodol Impurity 4 (Carisoprodol EP Impurity D)(Meprobamate)
Rabbit Anti-8-OHdG (DNA/RNA Damage) antibody
2-amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
8-oxo-2'-deoxyGuanosine
2'-Deoxy-7,8-dihydro-8-oxoguanosine
2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7,8,9-tetrahydro-3H-purine-6,8-dione
88847-89-6
8847-89-6
Bases & Related Reagents
Labeling and Diagnostics Reagents
Nucleotides
Heterocycles