ChemicalBook >> CAS DataBase List >>6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole structure

CAS No.: 1254036-71-9

Chemical Name:: 6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

Synonyms: CS-2340;Nemiralisib;GSK2269557 (free base);Nemiralisib(GSK2269557);gsk2269557(Nemiralisib);GSK 2269557;GSK-2269557;PI3Kδ inhibitor GS2269557;PI3Kδ inhibitor GS2269557;Nemiralisib (GSK2269557 free base);6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole

CBNumber:: CB63106826

Molecular Formula:: C26H28N6O

Molecular Weight:: 440.54

MDL Number:: MFCD28128611

MOL File:: 1254036-71-9.mol

Last updated:2023-05-21 10:59:17

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6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Properties

Boiling point	706.2±70.0 °C(Predicted)
Density	1.281±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 33.33 mg/mL (75.66 mM)
pka	12.90±0.40(Predicted)
FDA UNII	OEP8JJ3OZR

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-5683	Nemiralisib 99.50%	1254036-71-9	1mg	$84	2021-12-16	Buy
ChemScene	CS-5683	Nemiralisib 99.50%	1254036-71-9	5mg	$144	2021-12-16	Buy
ChemScene	CS-5683	Nemiralisib 99.50%	1254036-71-9	10mg	$228	2021-12-16	Buy
Matrix Scientific	148001	1H-Indazole	1254036-71-9	5mg	$482	2021-12-16	Buy
ChemScene	CS-5683	Nemiralisib 99.50%	1254036-71-9	25mg	$492	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-5683	1mg	$84	Buy
CS-5683	5mg	$144	Buy
CS-5683	10mg	$228	Buy
148001	5mg	$482	Buy
CS-5683	25mg	$492	Buy

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Chemical Properties,Uses,Production

Biological Activity

Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9).

in vivo

Nemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and T_pe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed.

target

Target	Value
PI3Kδ (Cell-free assay)	9.9(pKi)

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Jiangsu shring Biopharma Co., Ltd.	+8613372282299	sales@shringchem.com	China	3545	58
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4664	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Miaoyin Technology Co.,Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Jiangsu shring Biopharma Co., Ltd.	58
Dalian Meilun Biotech Co., Ltd.	58
MedChemexpress LLC	58

6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole GSK2269557 (free base) 1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]- PI3Kδ inhibitor GS2269557 CS-2340 gsk2269557(Nemiralisib) Nemiralisib(GSK2269557) Nemiralisib (GSK2269557 free base) GSK 2269557;GSK-2269557 Nemiralisib PI3Kδ inhibitor GS2269557 1254036-71-9 C26H28N6O