ML-031
- CAS No.
- 852230-33-2
- Chemical Name:
- ML-031
- Synonyms
- ML-031;CYM-5482;1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-;cancer,LPL Receptor,Inhibitor,ML031,inhibit,S1PR2,CYM-5482,CYM 5482,CYM5482,Lysophospholipid Receptor,ML 031
- CBNumber:
- CB63152681
- Molecular Formula:
- C19H20N2O3
- Molecular Weight:
- 324.3737
- MDL Number:
- MFCD06675163
- MOL File:
- 852230-33-2.mol
ML-031 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15171 | ML-031 ≥95% | 852230-33-2 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15171 | ML-031 ≥95% | 852230-33-2 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 15171 | ML-031 ≥95% | 852230-33-2 | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 15171 | ML-031 ≥95% | 852230-33-2 | 25mg | $374 | 2024-03-01 | Buy |
| ApexBio Technology | C5718 | ML-031 | 852230-33-2 | 25mg | $424 | 2021-12-16 | Buy |
ML-031 Chemical Properties,Uses,Production
Definition
ChEBI: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]pyrrolidine-2,5-dione is an aromatic ketone.
Biological Activity
ml-031 is an agonist of s1p2 with ec50 value of 1 μm [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. sphingolipids belong to a family of bioactive molecules with cell signaling properties. sphingosine 1-phosphate (s1p) is widely expressed on various tissues and cell types. s1p is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. until now, five sphingosine-1-phosphate receptors (s1pr1-s1pr5) have been identified. s1pr4 and s1pr5 are prominently expressed in the immune and nervous systems, respectively. s1p functions by binding to five distinct g protein-coupled receptors, s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8.ml-031 activated s1p2 with an ec50 value of 1 μm in a s1p reporter assay [1].
References
[1] satsu h, schaeffer m t, guerrero m, et al. a sphingosine 1-phosphate receptor 2 selective allosteric agonist[j]. bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
ML-031 Preparation Products And Raw materials
Raw materials
Preparation Products
ML-031 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |