Dehydrocorydaline chloride
- CAS No.
- 10605-03-5
- Chemical Name:
- Dehydrocorydaline chloride
- Synonyms
- Dehydrocorydaline chloride;13-Methylpalmatine chloride;Dehydrocorydaline chloride, 99.95%;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor
- CBNumber:
- CB63152944
- Molecular Formula:
- C22H24ClNO4
- Molecular Weight:
- 401.88326
- MDL Number:
- MFCD01937870
- MOL File:
- 10605-03-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H316 | |||||||||
| Precautionary statements | P501-P270-P264-P332+P313-P301+P310+P330-P405 | |||||||||
| HS Code | 2933399990 | |||||||||
| Toxicity | mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561, | |||||||||
| NFPA 704 |
|
Dehydrocorydaline chloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6061 | Dehydrocorydaline(chloride) 98.64% | 10605-03-5 | 5mg | $228 | 2021-12-16 | Buy |
| Apolloscientific | BISN0281 | Dehydrocorydaline chloride | 10605-03-5 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-6061 | Dehydrocorydaline(chloride) 98.64% | 10605-03-5 | 10mg | $348 | 2021-12-16 | Buy |
| Apolloscientific | BISN0281 | Dehydrocorydaline chloride | 10605-03-5 | 10mg | $378 | 2021-12-16 | Buy |
| ApexBio Technology | N2090 | Dehydrocorydalinechloride | 10605-03-5 | 20mg | $450 | 2021-12-16 | Buy |
Dehydrocorydaline chloride Chemical Properties,Uses,Production
Biological Activity
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. .
in vitro
Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression.
in vivo
Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice.
target
p38 MAPK
Dehydrocorydaline chloride Preparation Products And Raw materials
Dehydrocorydaline chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 9946 | 58 |