| Company Name: |
MedChemexpress LLC
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| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:Dehydrocorydaline (chloride)
CAS:10605-03-5
Purity:>98% Package:1900RMB/5mg
|
| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Dehydrocorydaline (chloride)
CAS:10605-03-5
Purity:99% Package:10mg
|
|
| | Dehydrocorydaline chloride Basic information |
| Product Name: | Dehydrocorydaline chloride | | Synonyms: | Dehydrocorydaline chloride;Dehydrocorydaline chloride, 99.95%;13-Methylpalmatine chloride;inhibit,Bcl-2 Family,Dehydrocorydaline chloride,Autophagy,PARP,poly ADP ribose polymerase,Caspase,13-Methylpalmatine,Dehydrocorydaline,p38 MAPK,Parasite,Inhibitor | | CAS: | 10605-03-5 | | MF: | C22H24ClNO4 | | MW: | 401.88326 | | EINECS: | | | Product Categories: | | | Mol File: | 10605-03-5.mol |  |
| | Dehydrocorydaline chloride Chemical Properties |
| Melting point | 191-193 °C (decomp) | | storage temp. | Store at -20°C | | solubility | DMSO: 20 mg/ml | | form | A solid |
| HS Code | 2933399990 | | Toxicity | mouse,LD50,intravenous,9500ug/kg (9.5mg/kg),United States Patent Document. Vol. #3849561, |
| | Dehydrocorydaline chloride Usage And Synthesis |
| Biological Activity | Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. . | | in vitro | Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. | | in vivo | Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice. | | target | |
| | Dehydrocorydaline chloride Preparation Products And Raw materials |
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