KT5720
- CAS No.
- 108068-98-0
- Chemical Name:
- KT5720
- Synonyms
- KT5720;Aids004395;Aids-004395;KT-5720 (KT5720);Antibiotic KT 5720;InSolution? KT5720;PROTEIN KINASE INHIBITOR KT 5720;KT5720 Antibiotic KT 5720;KT5720 - CAS 108068-98-0 - Calbiochem;InSolution KT5720 - CAS 108068-98-0 - Calbiochem
- CBNumber:
- CB6665746
- Molecular Formula:
- C32H31N3O5
- Molecular Weight:
- 537.61
- MDL Number:
- MFCD09878277
- MOL File:
- 108068-98-0.mol
| Boiling point | 715.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | methanol: 5 mg/mL |
| form | powder |
| pka | 11.96±0.40(Predicted) |
| color | white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | 58HV29I28S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P271 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | - | |||||||||
| F | 10 | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
KT5720 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K3761 | KT 5720 ≥98% (HPLC), powder | 108068-98-0 | 0.1mg | $259 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420320 | KT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. | 108068-98-0 | 50μG | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420323 | InSolution KT5720 - CAS 108068-98-0 - Calbiochem | 108068-98-0 | 50μg | $159 | 2024-03-01 | Buy |
| Sigma-Aldrich | 420320 | KT5720 - CAS 108068-98-0 - Calbiochem A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. | 108068-98-0 | 100μG | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 10011011 | KT 5720 ≥98% | 108068-98-0 | 50μg | $81 | 2024-03-01 | Buy |
KT5720 Chemical Properties,Uses,Production
Description
Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-
Chemical Properties
White solid
Uses
KT 5720 is a potent, specific and cell-permeable inhibitor of PKA.
Definition
ChEBI: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3- arboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol- -one.
Biological Activity
Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase. Also available as part of the Mixed Kinase Inhibitor Tocriset™ and PKA Tocriset™ .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1) Kase et al. (1987), K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Cabell et al. (1993), Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons; Int. J. Dev. Neurosci., 11 357
KT5720 Preparation Products And Raw materials
Raw materials
Preparation Products
KT5720 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| TargetMol Chemicals Inc. | 021-33632979 15002134094 | marketing@targetmol.com | China | 7934 | 58 |
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