Mosapride citrate
- CAS No.
- 112885-42-4
- Chemical Name:
- Mosapride citrate
- Synonyms
- as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapridecitrate/TAK-370citrate/AS-4370citrate
- CBNumber:
- CB6696030
- Molecular Formula:
- C27H33ClFN3O10
- Molecular Weight:
- 614.02
- MDL Number:
- MFCD00874415
- MOL File:
- 112885-42-4.mol
- MSDS File:
- SDS
Melting point | 143-145° |
---|---|
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) |
form | Solid |
color | White to Off-White |
Stability | Hygroscopic |
CAS DataBase Reference | 112885-42-4(CAS DataBase Reference) |
FDA UNII | MF497J489P |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H332-H335 | |||||||||
Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
Toxicity | LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera) | |||||||||
NFPA 704 |
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Mosapride citrate price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 30048 | Mosapride (citrate) | 112885-42-4 | 10mg | $57 | 2024-03-01 | Buy |
Cayman Chemical | 30048 | Mosapride (citrate) | 112885-42-4 | 250mg | $887 | 2024-03-01 | Buy |
Cayman Chemical | 30048 | Mosapride (citrate) | 112885-42-4 | 50mg | $208 | 2024-03-01 | Buy |
Cayman Chemical | 30048 | Mosapride (citrate) | 112885-42-4 | 100mg | $384 | 2024-03-01 | Buy |
Tocris | 2844 | Mosapridecitrate ≥99%(HPLC) | 112885-42-4 | 50 | $459 | 2021-12-16 | Buy |
Mosapride citrate Chemical Properties,Uses,Production
Description
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
Uses
Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.
Uses
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
Biological Activity
5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
storage
room temperature (desiccate)
Mosapride citrate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chongqing Ensky Pharmaceutical Co.,Ltd. | +86-23-86815286 +86-13983794297 | sales@ensky-chemical.com | China | 91 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from Mosapride citrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Mosapride citrate
112885-42-4
|
US $0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2022-09-20 | Mosapride citrate
112885-42-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-11-04 | Mosapride citrate
112885-42-4
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
- Mosapride citrate
112885-42-4
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Mosapride citrate
112885-42-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- Mosapride citrate
112885-42-4
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
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