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Pyridoxal 5'-phosphate monohydrate

CAS No.
41468-25-1
Chemical Name:
Pyridoxal 5'-phosphate monohydrate
Synonyms
PLP;PYRIDOXAL 5-PHOSPHATE MONOHYDRATE;5-Phosphate Monohydrate;PYRIDOXAL PHOSPHATE MONOHYDRATE;Pyridoxal 5-phosphate monohydrate(PLP);(4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate;Plp1;ACR1;B116;AOEB116
CBNumber:
CB6757175
Molecular Formula:
C8H12NO7P
Molecular Weight:
265.16
MDL Number:
MFCD00149414
MOL File:
41468-25-1.mol
MSDS File:
SDS
Last updated:2024-01-10 18:10:36

Pyridoxal 5'-phosphate monohydrate Properties

Melting point 140-143 °C(lit.)
storage temp. 2-8°C
solubility Acetonitrile (Slightly), DMSO (Slightly)
form Crystalline Powder
color Pale yellow
Water Solubility 5 g/L (20 ºC)
Sensitive Light Sensitive
Merck 14,7979
BRN 234749
Stability Air Sensitive, Moisture Sensitive
InChI InChI=1S/C8H10NO6P.H2O/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14;/h2-3,11H,4H2,1H3,(H2,12,13,14);1H2
InChIKey CEEQUQSGVRRXQI-UHFFFAOYSA-N
SMILES C1(COP(=O)(O)O)=CN=C(C)C(O)=C1C=O.O
CAS DataBase Reference 41468-25-1(CAS DataBase Reference)
FDA UNII 5V5IOJ8338

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  UV1208000
8-10-23
TSCA  Yes
HS Code  29333990
NFPA 704
1
0 0

Pyridoxal 5'-phosphate monohydrate price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 82870 Pyridoxal 5′-phosphate monohydrate ≥97.0% (NT) 41468-25-1 1g $71.3 2024-03-01 Buy
Sigma-Aldrich 82870 Pyridoxal 5′-phosphate monohydrate ≥97.0% (NT) 41468-25-1 5g $248 2024-03-01 Buy
Sigma-Aldrich SAB2501870 Anti-PDXP (C-terminal) antibody produced in goat affinity isolated antibody, buffered aqueous solution 100μG $568 2024-03-01 Buy
Sigma-Aldrich SRP6075 PRDX 5 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE) 100μG $483 2023-06-20 Buy
TCI Chemical C0377 Pyridoxal 5-Phosphate Monohydrate >98.0%(HPLC) 41468-25-1 1g $43 2024-03-01 Buy
Product number Packaging Price Buy
82870 1g $71.3 Buy
82870 5g $248 Buy
SAB2501870 100μG $568 Buy
SRP6075 100μG $483 Buy
C0377 1g $43 Buy

Pyridoxal 5'-phosphate monohydrate Chemical Properties,Uses,Production

Chemical Properties

Pyridoxal Phosphate Hydrate occurs as a pale yellow-white to light yellow crystalline powder.
It is slightly soluble in water, and practically insoluble in ethanol (99.5).
It dissolves in dilute hydrochloric acid and in sodium hydroxide TS.
The pH of a solution prepared by dissolving 0.1 g of Pyridoxal Phosphate Hydrate in 200 mL of water is between 3.0 and 3.5.
Pyridoxal Phosphate Hydrate is colored to light red by light.

Uses

Pyridoxal 5-phosphate (PLP) (active form of Vitamin B6) is an enzyme prosthetic group that acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into GABA; of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Definition

ChEBI: Pyridoxal 5-phosphate monohydrate is a pyridinecarbaldehyde.

Application

Pyridoxal 5′-phosphate (PLP), an active form of vitamin B6/ pyridoxine is the coenzyme of amino acid metabolism.
Pyridoxal 5′-phosphate monohydrate has been used:
as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay
as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children
as a dietary supplement to study its effects on the lethal phenotype of mutant flies.

Biosynthesis

Two distinct pathways for Pyridoxal 5′-phosphate (PLP) biosynthesis are known. 1.The 'DXP dependent' pathway is found in Escherichia coli and a few members of the γ subdivision of proteobacteria and has been extensively characterized. In this pathway deoxyxylulose 5-phosphate (DXP) is condensed with 3-hydroxy-1-aminoacetone phosphate to give PNP. PNP is oxidized to PLP by PdxH. The DXP dependent pathway is not widely distributed and is surprisingly complex requiring seven enzymes (GapB, PdxB, PdxF (SerC), PdxA, DXS, PdxJ and PdxH). This pathway was the first discovered and it has been extensively reviewed. 2. The second pathway uses Pdx1 and Pdx2 to catalyze the condensation of d-ribose 5-phosphate (R5P), glutamine and glyceraldehyde 3-phosphate to form PLP. The mechanistic and structural characterization of both pathways is at an advanced stage.

General Description

Pyridoxal 5'-phosphate (PLP, vitamin B6) is an essential cofactor in all living systems. It is one of the most versatile cofactors and participates in transamination, decarboxylation, racemization, Cα-Cβ cleavage and α-β elimination reactions. PLP plays an important role in amino acid and carbohydrate metabolism and has been implicated in singlet oxygen resistance. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction. By inhibiting AGE formation and working as a coenzyme in chemical reactions, pyridoxal 5’-phosphate can support healthy nerve, eye, cardiovascular and kidney function.

Biological Activity

Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base.

Pyridoxal 5'-phosphate monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 517)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Weitai Biological Pharmaceutical Co.,Ltd.
+8613282012786 sales@weitai-pharmaceutical.com China 61 58
Maintain Biotech Co., Ltd.
+86-75589664337 +86-15112661142 cami@maintain-bio.com China 47 58
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Shaanxi Haibo Biotechnology Co., Ltd
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Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140 sales@zhswyy.com China 382 58
Henan Tianfu Chemical Co.,Ltd.
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Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
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008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
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+86-571-86589381,86589382,86589383 sales1@qqpharm.com CHINA 154 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60

Related Qustion

View Lastest Price from Pyridoxal 5'-phosphate monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyridoxal 5'-phosphate monohydrate pictures 2024-03-08 Pyridoxal 5'-phosphate monohydrate
41468-25-1
US $0.00-0.00 / kg 0.10000000149011612kg ≥99% 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
Pyridoxal 5'-phosphate monohydrate; P5P pictures 2024-03-08 Pyridoxal 5'-phosphate monohydrate; P5P
41468-25-1
US $0.00-0.00 / kg 0.10000000149011612kg ≥99% 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
Pyridoxal 5'-phosphate monohydrate pictures 2023-11-08 Pyridoxal 5'-phosphate monohydrate
41468-25-1
US $0.00-0.00 / KG 1KG 99% 10000 Mt/Year Shaanxi Haibo Biotechnology Co., Ltd
3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehydemonohydr Pyridoxal 5'-phosphate Monhydrate Pyridoxal 5-phosphate monohydrate,99% Pyridoxal 5′-phospha pyridoxal-5-monophosphoricacidestermonohydrate pyridoxylphosphatemonohydrate CODECARBOXYLASE CODECARBOXYLASE MONOHYDRATE 3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)-METHYL]-4-PYRIDINECARBOXALDEHYDE, MONOHYDRATE 5'-phosphate Pyridoxal-5-monophosphoric acid ester PYRIDOXAL-5-PHOSPHATE H2O PYRIDOXAL 5'-PHOSPHATE MONOHYDRATE PYRIDOXAL-5-PHOSPHORIC ACID H2O PYRIDOXAL-5-PHOSPHORIC ACID, MONOHYDRATE Pyridoxal 5'-phosphate hydrate PYRIDOXAL-5'-PHOSPHATE MONOHYDRATE BIOSY NTH PYRIDOXAL 5-PHOSPHATE CELL CULTURE*TESTE D Anti-PDXP (C-terminal) antibody produced in goat FLJ32703 pyridoxal (pyridoxine, vitamin B6) phosphatase MONOCLONAL ANTI-RAT PIP1 (CENTER) antibody produced in mouse Plp1 ACR1 AOEB116 B116 Peroxiredoxin 5 PRDX 5 human 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-(phosphonooxy)methyl-, monohydrate 3-hydroxy-2-methyl-5-((phosphonooxy)methyl)-4-pyridinecarboxaldehydmonoh 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde5-phosphatemonohydrat phosphopyridoxalmonohydrate pyridoxal,5-(dihydrogenphosphate),monohydrate PYRIDOXAL-5-PHOSPHATEextrapure Codecarboxylase, PLP, Pyridoxal 5-phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate monohydrate Pyridoxal 5-phosphate Monohydrate, 99% 1GR (4-formyl-5-hydroxy-6-methyl-3-pyridyl)methyl dihydrogen phosphate hydrate (4-formyl-5-hydroxy-6-methyl-3-pyridinyl)methyl phosphate Pyridoxal Impurity 1 Pyridoxal 5-Phosphate Monohydrate> (4-Formyl-5-hydroxy-6-methyl-3-pyridyl)methyl dihydrogen phosphate monohydrate Pyridoxal 5'-phosphate monohydrate ISO 9001:2015 REACH Pyridoxal-5-phosphate 1-hydrate Pyridoxal 5′-phosphate, monohydrate, 98%+ Pyridoxal 5'-phosphate hydrate 98% (HPLC) Pyridoxal-5-Phosphate Monohydrate extrapure, 98% [(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid hydrate Pyridoxal 5-phosphate monohydrate(PLP) PLP PYRIDOXAL PHOSPHATE MONOHYDRATE PYRIDOXAL 5-PHOSPHATE MONOHYDRATE (4-ForMyl-5-hydroxy-6-Methylpyridin-3-yl)Methyl dihydrogen phosphate hydrate 5-Phosphate Monohydrate yridoxine -5 -phosphate Pyridoxal5-phosphatemonohydrate,9Chemicalbook9% Pyridoxl 5'phosphate (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyldihydrogenphosphatehydrate(1:1)