Spermidine trihydrochloride

Spermidine trihydrochloride Properties

Melting point	257-259 °C(lit.)
storage temp.	room temp
solubility	H₂O: 1 M at 20 °C, clear, colorless
form	Crystalline Powder
color	White
PH	3.0-6.0 (25℃, 1M in H2O)
Water Solubility	Soluble in water (100 mg/ml), and ethanol.
λmax	λ: 260 nm Amax: 0.2 λ: 280 nm Amax: 0.1
BRN	3552356
InChI	InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChIKey	LCNBIHVSOPXFMR-UHFFFAOYSA-N
SMILES	C(CCCN)NCCCN.Cl.Cl.Cl
CAS DataBase Reference	334-50-9(CAS DataBase Reference)
EWG's Food Scores	1-3
FDA UNII	1O14BED398
EPA Substance Registry System	1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

3

RTECS

EJ7023000

F

3-10

TSCA

Yes

HS Code

29212900

NFPA 704

	1
2		0

Spermidine trihydrochloride price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	85578	Spermidine trihydrochloride BioXtra, ≥99.5% (AT)	334-50-9	1g	$61.2	2024-03-01	Buy
Sigma-Aldrich	56766-M	Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.	334-50-9	5G	$259	2024-03-01	Buy
Alfa Aesar	J61595	Spermidine trihydrochloride, 99+%	334-50-9	100mg	$66.65	2024-03-01	Buy
Sigma-Aldrich	S2501	Spermidine trihydrochloride ≥98% (TLC)	334-50-9	1g	$42.7	2024-03-01	Buy
Sigma-Aldrich	S2501	Spermidine trihydrochloride ≥98% (TLC)	334-50-9	5g	$138	2024-03-01	Buy

Product number	Packaging	Price	Buy
85578	1g	$61.2	Buy
56766-M	5G	$259	Buy
J61595	100mg	$66.65	Buy
S2501	1g	$42.7	Buy
S2501	5g	$138	Buy

Spermidine trihydrochloride Chemical Properties,Uses,Production

Description

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

Chemical Properties

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

Chemical Reactivity

Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure.

Uses

Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

Definition

Spermidine trihydrochloride powder is the trihydrochloride form of spermidine. Spermidine base is in liquid form, while Spermidine trihydrochloride is in powder form. Spermidine trihydrochloride is a more stable form because spermidine is very air-sensitive. Spermidine trihydrochloride powder benefits are the same as Spermidine benefits.

benefits

Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.

Biological Functions

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

General Description

Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

Biological Activity

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.

storage

+4°C (desiccate)

Purification Methods

Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]

Spermidine trihydrochloride synthesis

Synthesis of Spermidine trihydrochloride from Carbamic acid, N-[4-[[3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl]amino]butyl]-, 1,1-dimethylethyl ester

Spermidine trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Spermidine trihydrochloride Suppliers

Global( 282)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Konberd Biotech Co., Ltd	+undefined18986093962	admin@konberdbio.com	China	1376	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	874	58
Bonerge(Hunan) Lifescience Co., Ltd.	+86-731-82791134 +86-18801900056	hank.h@bonerge.com	China	30	58
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	66	58
Suzhou Yuanrui Bio-Tech Co., Ltd	+86-18106132862 +86-18106132862	sales02@yuanruibio.com	China	278	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Hangzhou Zelixir Biotech Co., Ltd.	+8618867646786	neal.chen@zelixir.com	China	229	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55

Supplier	Advantage
Wuhan Konberd Biotech Co., Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
Bonerge(Hunan) Lifescience Co., Ltd.	58
Maintain Biotech Co., Ltd.	58
Suzhou Yuanrui Bio-Tech Co., Ltd	58
GIHI CHEMICALS CO.,LIMITED	58
Wuhan Haorong Biotechnology Co.,ltd	58
Hangzhou Zelixir Biotech Co., Ltd.	58
airuikechemical co., ltd.	58
Shanghai Bojing Chemical Co.,Ltd.	55

View Lastest Price from Spermidine trihydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Spermidine trihydrochloride 34-50-9	US $0.00 / G	1G	99	20	CONTIDE BIOTECH CO.,LTD
2024-04-26	Spermidine trihydrochloride 334-50-9	US $0.00-0.00 / kg	1kg	99%	3000kg	Jinan Jianfeng Chemical Co., Ltd
2024-04-25	Natural biosynthesis of spermidine HCL 334-50-9	US $0.00-0.00 / kg	0.1kg	≥98%	50kg	Hangzhou Zelixir Biotech Co., Ltd.

Spermidine trihydrochloride
34-50-9
US $0.00 / G
99
CONTIDE BIOTECH CO.,LTD

Spermidine trihydrochloride
334-50-9
US $0.00-0.00 / kg
99%
Jinan Jianfeng Chemical Co., Ltd

Natural biosynthesis of spermidine HCL
334-50-9
US $0.00-0.00 / kg
≥98%
Hangzhou Zelixir Biotech Co., Ltd.

Spermidine trihydrochloride Spectrum

Spermidine trihydrochloride(334-50-9)FT-IR Spermidine trihydrochloride(334-50-9)IR Spermidine trihydrochloride(334-50-9)Raman

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4-butanediamine,n-(3-aminopropyl)-trihydrochloride 4-azoniaoctamethylenediammonium trichloride 1,8-DIAMINO-4-AZAOCTANE TRIHYDROCHLORIDE SPERMIDINE TRIHYDROCHLORIDE N-(3-AMINOPR OPYL)-1,4 Spermidine trihydrochloride, 99+% Spermidine·3hydrochloride SPERMIDINE 3HC SPERMIDINE.3HCLRESEARCH GRADE SPERMIDINE *3HClMOLECULAR BIOLOGY GRADE Spermidine trihydrochloride,N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride SperMidine trihydrochloride, 99+% 5GR N1-(3-AMinopropyl)butane-1,4-diaMine trihydrochloride N-(3-aMinopropyl)butane-1,4-diaMinetrihydrochloride SperMidine tri SPERMIDINE TRIHYDROCHLORIDE BIOXTRA N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H CL N-(3-AMINOPROPYL)-1 4-BUTANEDIAMINE HYDROCHLORIDE N-(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TRIHYDROCHLORIDE N-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE 3HCL N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE SPERMIDINE 3HCL SPERMIDINE TRIHYDROCHLORIDE 1,4-Butanediamine,N-(3-aminopropyl)-,trihydrochloride Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem Spermidine trihydrochloride, ≥98(TLC) 4-Azaoctamethylenediamine trihydrochloride SPERMIDINE TRIHYDROCHLORIDE ISO 9001：2015 REACH Spermidine trihydrochloride 98% Spermidine trihydrochloride 5% SPERMIDINE HCl Spermidie 3HCL SPERMIDINE HYDROCHLORIDE N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H C Spermidine 3HCl>98% Natural biosynthesis of spermidine HCL 334-50-9 34-50-9 C7H19N3x3HCl C7H19N33HCl C7H19N3HCl NH2CH23NHCH24NH23HCl C7H19N33ClH BioChemika Ultra Application Index Cell Signaling Enzymes Biochemicals and Reagents Building Blocks BioChemical Amine Salts NOS Inhibitors Substrate Analogs Enzyme Inhibitors Enzyme Inhibitors by Type Enzymes, Inhibitors, and Substrates Crystallization Nitrogen Compounds Nitric Oxide Metabolism Organic Building Blocks