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Ginsenoside Rb1

Ginsenoside Rb1 Structure
Ginsenoside Rb1 structure
CAS No.
41753-43-9
Chemical Name:
Ginsenoside Rb1
Synonyms
GYPENOSIDE;GINSENOSIDE GINSENOSIDE-RB1;(3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside;NSC 310103;Gypenoside I;arasaponine1;gynosaponinc;Gypenoside Ⅲ;gypenosideiii;panaxsaponine
CBNumber:
CB7237661
Molecular Formula:
C54H92O23
Molecular Weight:
1109.29
MDL Number:
MFCD00133367
MOL File:
41753-43-9.mol
MSDS File:
SDS
Last updated:2024-03-26 17:16:27
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Ginsenoside Rb1 Properties

Melting point 197.5°C
Boiling point 766.35°C (rough estimate)
Density 1.0971 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
pka 12.85±0.70(Predicted)
color Off-White to Pale Beige
Stability Hygroscopic
InChIKey GZYPWOGIYAIIPV-VOKNSFSUNA-N
LogP 2.900 (est)
CAS DataBase Reference 41753-43-9(CAS DataBase Reference)
FDA UNII 7413S0WMH6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn,Xi,T,F
Risk Statements  20/21/22-39/23/24/25-23/24/25-11
Safety Statements  26-36-45-36/37-16-7
WGK Germany  3
RTECS  LZ5856000
HS Code  29389090
Toxicity oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76
NFPA 704
0
3 0

Ginsenoside Rb1 price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G0777 Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root triterpenoid saponin 41753-43-9 5mg $652 2024-03-01 Buy
Sigma-Aldrich 00170580 Ginsenoside Rb1 primary pharmaceutical reference standard 41753-43-9 10mg $766 2024-03-01 Buy
Cayman Chemical 15319 Ginsenoside Rb1 ≥98% 41753-43-9 5mg $93 2024-03-01 Buy
Cayman Chemical 15319 Ginsenoside Rb1 ≥98% 41753-43-9 10mg $176 2024-03-01 Buy
Sigma-Aldrich Y0001347 Ginsenoside Rb1 European Pharmacopoeia (EP) Reference Standard 41753-43-9 y0001347 $220 2024-03-01 Buy
Product number Packaging Price Buy
G0777 5mg $652 Buy
00170580 10mg $766 Buy
15319 5mg $93 Buy
15319 10mg $176 Buy
Y0001347 y0001347 $220 Buy

Ginsenoside Rb1 Chemical Properties,Uses,Production

Description

Ginsenoside Rb1, a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.

Uses

A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.

Uses

Reference standard in the analysis of herbal medicinal products.

Definition

ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.

benefits

Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].

General Description

Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.

Biochem/physiol Actions

Triterpene saponin found in ginseng.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes.

target

p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor

References

[1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.

Ginsenoside Rb1 Preparation Products And Raw materials

Raw materials

Preparation Products

Ginsenoside Rb1 Suppliers

Global( 380)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-19164747840 +86-13119157289 13119157289@163.com China 2971 58
Xi'an ZB Biotech Co.,Ltd
+8618591943808 sales01@xazbbio.com China 816 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8618829768577 gao490372054@gamil.com China 1250 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7933 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15933 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
Supplier Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
Xi'an ZB Biotech Co.,Ltd
58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55

View Lastest Price from Ginsenoside Rb1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ginsenoside Rb1 pictures 2024-04-28 Ginsenoside Rb1
41753-43-9
 US $0.00 / kg 0.1kg 50%-98% HPLC 100kg Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Ginsenoside Rb1 pictures 2024-04-28 Ginsenoside Rb1
41753-43-9
 US $0.00 / MG 20MG >95% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
Ginsenoside Rb1 pictures 2024-04-28 Ginsenoside Rb1
41753-43-9
 US $0.00 / MG 20MG >95% HPLC 1000KG Changsha Staherb Natural Ingredients Co., Ltd.
  • Ginsenoside Rb1 pictures
  • Ginsenoside Rb1
    41753-43-9
  • US $0.00 / kg
  • 50%-98% HPLC
  • Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
  • Ginsenoside Rb1 pictures
  • Ginsenoside Rb1
    41753-43-9
  • US $0.00 / MG
  • >95% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Ginsenoside Rb1 pictures
  • Ginsenoside Rb1
    41753-43-9
  • US $0.00 / MG
  • >95% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.

Ginsenoside Rb1 Spectrum

Ginsenoside Rb1(41753-43-9)MS

41753-43-9(Ginsenoside Rb1 )Related Search:

Ginsenoside Rg2 TRIBULOSIDE GINSENOSIDE RE Ginsenoside Rg1 Ginsenoside Re
Ginsenoside Rh2 GinsenosideRo 20(R)-Ginsenoside Rg3 Ginsenoside Rd Ginsenoside Rb3 (CAS#68403-26-8),GINSENOSIDE RB3
GINSENOSIDE RB2,GINSENOSIDE Rb2 hplc,GINSENOSIDE RB2 WITH HPLC Panaxadiol Panaxatriol Ginsenoside Rg3 Ginsenoside-Rg5
Ginsenoside Rh1 Ginsenoside Rk3 GINSENOSIDEF1

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GINSENOSIDE RB1 GINSENOSIDE RBL 2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside Ginsenoside Rb1 std. ginsenoside-rb1from panax quinquefolium (american ginseng)root Ginsenoside Rb1 (CAS# 41753-43-9) GinsenosideRB1,SanchinosideE1 GINSENOSIDE Rb1 hplc Gensenoside Rb1 GINSENOSIDE RB1 WITH HPLC glucopyranosyl-β-D-glucopyranosyl)oxy]-12- hydroxydammar-24-en-3-yl2-O-β-D-glucopyra Notoginsenoside Rb1 Panaxoside Rb1 β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D- Gypenoside I hydroxydammar-24-en-3-yl O-6-deoxy-α-L- mannopyranosyl-(1→6)-O-[β-D- (20S)-3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol [20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl]2-O-β-D-glucopyranosyl-β-D-glucopyranoside 3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol ginsenoside-Rb1 standard (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-beta-d-glucopyranosid arasaponine1 glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl- gynosaponinc gypenosideiii panaxsaponine pseudoginsenosided SANCHINOSIDE E1 Ginsenoside Rb1 ,98% (3β,12β)-20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydaMMar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside Purity of Ginsenoside Rg1 NSC 310103 Sanchinoside Rb1 Ginsenoside Rb1, froM Panax ginseng Ginsenoside Rb1 (saponin of panax ginseng) Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root 2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside (3beta,12beta)-20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-O-beta-D-glucopyranosyl-beta-D-glucopyranosi Ginsenoside Rb1 41753-43-9 Ginsenoside Rb1, 98%, from Panax ginseng C. A. Mey. Ginsenoside Rb1 CRS Ginsenoside Rb1 RS Gypenoside Ⅲ β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl- (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3, GINSENOSIDE GINSENOSIDE-RB1 (3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside GYPENOSIDE (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Rb1 Ginsenoside Rb1 41753-43-9 41753-53-9 C54H92O23 C60H102O27 chemical reagent