BVT 2733
- CAS No.
- 376640-41-4
- Chemical Name:
- BVT 2733
- Synonyms
- BVT2733, >98%;BVT 2733(BVT.2733);BVT.2733 >=98% (HPLC);3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide;BENZENESULFONAMIDE, 3-CHLORO-2-METHYL-N-[4-[2-(4-METHYL-1-PIPERAZINYL)-2-OXOETHYL]-2-THIAZOLYL]-;3-CHLORO-2-METHYL-N-[4-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHYL]-1,3-THIAZOL-2-YL]BENZENESULFONAMIDE;HFD,CIA,BVT-2733,J774.1,arthritis,macrophage,collagen,inhibit,BVT2733,BVT 2733,disease,adipocyte,Inhibitor,obesity
- CBNumber:
- CB72667358
- Molecular Formula:
- C17H21ClN4O3S2
- Molecular Weight:
- 428.96
- MDL Number:
- MFCD13152134
- MOL File:
- 376640-41-4.mol
- MSDS File:
- SDS
| Boiling point | 636.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.427±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≥42.9 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 6.36±0.10(Predicted) |
| FDA UNII | 2EGD70329U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| HS Code | 2935909099 | |||||||||
| NFPA 704 |
|
BVT 2733 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1205 | BVT.2733 ≥98% (HPLC) | 376640-41-4 | 5MG | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1205 | BVT.2733 ≥98% (HPLC) | 376640-41-4 | 25MG | $370 | 2024-03-01 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 10mg | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 22203 | BVT 2733 ≥98% | 376640-41-4 | 25mg | $400 | 2024-03-01 | Buy |
BVT 2733 Chemical Properties,Uses,Production
Uses
BVT 2733 is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1.
Biological Activity
ki: 1 μm using 11-dehydrocorticosterone as substratebvt 2733 is a novel, small molecule, non-steroidal, and selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-hsd1).11β-hsd1 has been reported to alter glucocorticoid hormone action in target tissues for insulin action and is suggested to play a key role in glucose homeostasis.
in vitro
bvt 2733 was identified as a novel type 1 selective inhibitor of murine 11β-hsd1 (ki 1 μmol/l), which did not inhibit mouse 11β-hsd type 2 at a concentration as high as 200 μmol/l (corresponding to a ki >33 μmol/l). therefore, the selectivity of bvt 2733 for the 11β-hsd type 1 enzyme over the type 2 enzyme was estimated to be at least 30-fold based on the ki values [1].
in vivo
in mice, bvt 2733 treatment could lower hepatic pepck and glucose-6-phosphatase mrna, serum insulin and blood glucose concentrations compared with vehicle treated mice. in contrast, hepatic 11beta-hydroxysteroid dehydrogenase type 1 mrna, liver function marker enzyme expression including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatases, body weight as well as daily food intake were not changed by the treatment of bvt 2733 [1].
References
[1] alberts p,engblom l,edling n,forsgren m,klingstrm g,larsson c,rnquist-nii y,ohman b,abrahmsén l. selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. diabetologia.2002 nov;45(11):1528-32.
BVT 2733 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
View Lastest Price from BVT 2733 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
376640-41-4
|
US $1.00 / KG | 1KG | 95%~99% | per week 100kg | Career Henan Chemical Co |
-
- 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide
376640-41-4
- US $1.00 / KG
- 95%~99%
- Career Henan Chemical Co