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CD152:FC (HUMAN)-MULG FUSION PROTEIN

CD152:FC (HUMAN)-MULG FUSION PROTEIN Structure
CD152:FC (HUMAN)-MULG FUSION PROTEIN structure
CAS No.
Chemical Name:
CD152:FC (HUMAN)-MULG FUSION PROTEIN
Synonyms
CD152/FC CHIMERA, CYTOLYTIC;CTLA4/FC CHIMERA, CYTOLYTIC;CD152-FC FUSION PROTEIN, HUMAN;CD152/FC CHIMERA, NON-CYTOLYTIC;CTLA4/FC CHIMERA, NON-CYTOLYTIC;CTLA-4 MULG FUSION PROTEIN, HUMAN;CD152:FC (HUMAN)-MULG FUSION PROTEIN;CTLA-4:FC (HUMAN)-MULG FUSION PROTEIN;CD152/Fc Chimera, Cytolytic from mouse;CD152/Fc Chimera, Non-cytolytic from mouse
CBNumber:
CB7275351
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD01092888
MOL File:
Mol file
Last updated:2023-04-23 13:52:06
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CD152:FC (HUMAN)-MULG FUSION PROTEIN Properties

storage temp. -20°C
form buffered aqueous solution

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  -

CD152:FC (HUMAN)-MULG FUSION PROTEIN price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C4358 CD152/Fc Chimera, Non-cytolytic from mouse ≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized 1MG $612 2023-06-20 Buy
Product number Packaging Price Buy
C4358 1MG $612 Buy

CD152:FC (HUMAN)-MULG FUSION PROTEIN Chemical Properties,Uses,Production

General Description

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Biochem/physiol Actions

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

CD152:FC (HUMAN)-MULG FUSION PROTEIN Preparation Products And Raw materials

Raw materials

Preparation Products

CD152:FC (HUMAN)-MULG FUSION PROTEIN Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
CD152/FC CHIMERA, CYTOLYTIC CD152/FC CHIMERA, NON-CYTOLYTIC CD152-FC FUSION PROTEIN, HUMAN CD152:FC (HUMAN)-MULG FUSION PROTEIN CTLA4/FC CHIMERA, CYTOLYTIC CTLA4/FC CHIMERA, NON-CYTOLYTIC CTLA-4:FC (HUMAN)-MULG FUSION PROTEIN CTLA-4 MULG FUSION PROTEIN, HUMAN CD152/Fc Chimera, Cytolytic from mouse CD152/Fc Chimera, Non-cytolytic from mouse