| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:CD152/Fc Chimera, Non-cytolytic
Purity:>=98% (SDS-PAGE) Package:1mg Remarks:C4358
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Remarks:recombinant, expressed in NS.1 cells, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
Alexis Corporation
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| Tel: |
+41 61 926 8989 |
| Email: |
alexis-ch@alexis-corp.ch |
| Products Intro: |
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| | CD152:FC (HUMAN)-MULG FUSION PROTEIN Basic information |
| Product Name: | CD152:FC (HUMAN)-MULG FUSION PROTEIN | | Synonyms: | CD152/FC CHIMERA, CYTOLYTIC;CD152/FC CHIMERA, NON-CYTOLYTIC;CD152-FC FUSION PROTEIN, HUMAN;CD152:FC (HUMAN)-MULG FUSION PROTEIN;CTLA4/FC CHIMERA, CYTOLYTIC;CTLA4/FC CHIMERA, NON-CYTOLYTIC;CTLA-4:FC (HUMAN)-MULG FUSION PROTEIN;CTLA-4 MULG FUSION PROTEIN, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CD152:FC (HUMAN)-MULG FUSION PROTEIN Structure]() |
| | CD152:FC (HUMAN)-MULG FUSION PROTEIN Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | CD152:FC (HUMAN)-MULG FUSION PROTEIN Usage And Synthesis |
| General Description | The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). | | Biochem/physiol Actions | CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86. |
| | CD152:FC (HUMAN)-MULG FUSION PROTEIN Preparation Products And Raw materials |
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