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2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE structure

CAS No.: 384-67-8

Chemical Name:: 2-CHLORO-2,2-DIFLUOROACETOPHENONE

Synonyms: 2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone;ChlorodifluoroMethyl phenyl ketone

CBNumber:: CB7297366

Molecular Formula:: C8H5ClF2O

Molecular Weight:: 190.57

MDL Number:: MFCD00042123

MOL File:: 384-67-8.mol

MSDS File:: SDS

Last updated:2024-01-25 15:58:02

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2-CHLORO-2,2-DIFLUOROACETOPHENONE Properties

Melting point	102-103 °C
Boiling point	94-96 °C35 mm Hg(lit.)
Density	1.293 g/mL at 25 °C(lit.)
refractive index	n20/D 1.497(lit.)
Flash point	163 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Difficult to mix.
form	liquid
color	Clear, colourless
BRN	2251448
CAS DataBase Reference	384-67-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37

RIDADR

UN 3334

WGK Germany

Hazard Note

Irritant

HS Code

29147000

NFPA 704

	2
2		0

2-CHLORO-2,2-DIFLUOROACETOPHENONE price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	792373	2-Chloro-2,2-difluoroacetophenone 95%	384-67-8	10g	$179.4	2024-03-01	Buy
Sigma-Aldrich	792373	2-Chloro-2,2-difluoroacetophenone 95%	384-67-8	1g	$63.2	2023-06-20	Buy
Alfa Aesar	L16963	2-Chloro-2,2-difluoroacetophenone, 96%	384-67-8	1g	$96.65	2024-03-01	Buy
Alfa Aesar	L16963	2-Chloro-2,2-difluoroacetophenone, 96%	384-67-8	5g	$377.65	2024-03-01	Buy
TRC	C423215	2-Chloro-2,2-difluoroacetophenone	384-67-8	500mg	$75	2021-12-16	Buy

Product number	Packaging	Price	Buy
792373	10g	$179.4	Buy
792373	1g	$63.2	Buy
L16963	1g	$96.65	Buy
L16963	5g	$377.65	Buy
C423215	500mg	$75	Buy

2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Uses,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 2,2-difluoro-2-(methylthio)-1-phenyl- (9CI) 4-(Difluoromethoxy)-2-fluorobromobenzene

2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

Global( 116)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1377	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21149	58
Allfluoro pharmaceutical co. ltd.	021-26137118 +8615821363818	sales@allfluoro.com	China	5791	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	sales@win-winchemical.com	China	13854	58
Unipharm pharmaceutical industry Co., Ltd	536-8266195 +8613953676784	lee@unipharm-sd.com	China	1206	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Allfluoro pharmaceutical co. ltd.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
WinWin Chemical CO., Limited	58
Unipharm pharmaceutical industry Co., Ltd	58

View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-02-22	2-Chloro-2,2-difluoroacetophenone 384-67-8	US $0.00 / KG	1KG	97.8%	100 tons	Honest Joy Holdings Limited

2-Chloro-2,2-difluoroacetophenone
384-67-8
US $0.00 / KG
97.8%
Honest Joy Holdings Limited

384-67-8(2-CHLORO-2,2-DIFLUOROACETOPHENONE)Related Search:

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CHLORODIFLUOROACETOPHENONE alpha,alpha-Difluorophenacyl chloride 2-CHLORO-2,2-DIFLUOROACETOPHENONE A-CHLORO-A,A-DIFLUOROACETOPHENONE ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE ChlorodifluoroMethyl phenyl ketone 2-Chloro-2,2-d 2-chloro-2,2-difluoro-1-phenylethanone 2-chloro-2,2-difluoro-1-phenyl-ethanone à,à-difluorophenacyl chloride à-chloro-à,à-difluoroacetophene 2-Chloro-2,2-difluoroacetophenone 97% 2-Chloro-2,2-difluoroacetophenone97% 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96% 1-Phenyl-2,2-difluoro-2-chloroethanone Phenyl(chlorodifluoromethyl) ketone α,α-Difluoro-α-chloroacetophenone 2-Chloro-2,2-difluoro-1-phenylethan-1-one Ethanone, 2-chloro-2,2-difluoro-1-phenyl- 384-67-8 C6H5COCF2Cl Fluorine series