ChemicalBook >> CAS DataBase List >>(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile structure

CAS No.: 38321-02-7

Chemical Name:: (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile

Synonyms: d-Verapamil;Dexverapami;Dexverapamil;Dexverapamil Hydrochloride;[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile;(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile;(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile;Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-;Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-

CBNumber:: CB7941337

Molecular Formula:: C27H38N2O4

Molecular Weight:: 454.61

MDL Number:: MFCD00864679

MOL File:: 38321-02-7.mol

Last updated:2023-07-08 08:28:38

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(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Properties

Melting point	129-131°C
Boiling point	586.1±50.0 °C(Predicted)
Density	1.058±0.06 g/cm3(Predicted)
pka	8.97±0.50(Predicted)
FDA UNII	QR5PYD126V
NCI Drug Dictionary	dexverapamil

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0000091	R(+)-VERAPAMIL 95.00%	38321-02-7	1MG	$757.97	2021-12-16	Buy
American Custom Chemicals Corporation	API0000091	R(+)-VERAPAMIL 95.00%	38321-02-7	10MG	$2243.59	2021-12-16	Buy
Medical Isotopes, Inc.	14156	(R)-(+)-VerapamilHCl	38321-02-7	5mg	$2400	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0000091	1MG	$757.97	Buy
API0000091	10MG	$2243.59	Buy
14156	5mg	$2400	Buy

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells

Definition

ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile synthesis

Synthesis of (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile from N-Methylhomoveratrylamine and Benzeneacetonitrile, α-(3-chloropropyl)-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Suppliers

Global( 12)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9685	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
QUALITY CONTROL SOLUTIONS LTD.	13670046396	ORDERS@QCSRM.COM	China	18820	58
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18488	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Supplier	Advantage
LGM Pharma	70
Clearsynth Labs Limited	58
Energy Chemical	58
QUALITY CONTROL SOLUTIONS LTD.	58
Changzhou Bojia Biomedical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

38321-02-7((+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile)Related Search:

(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile 2-(4-Methoxyphenyl)-2-methylpropanenitrile Devapamil (+/-)-Verapamil hydrochloride METHOXY-(-)-VERAPAMIL HYDROCHLORIDE

R(+)-VERAPAMIL HYDROCHLORIDE 3-Methyl-2-(3,4-dimethoxyphenyl)butyronitrile 4-HYDROXY-3-METHOXYPHENYLACETONITRILE Verapamil (3,4-Dimethoxyphenyl)acetonitrile

Benzeneacetonitrile Valeronitrile P-O-DESMETHYL VERAPAMIL 1-(3,4-DIMETHOXYPHENYL)-VALERONITRILE NORVERAPAMIL

Emopamil 2-(3-METHOXYPHENYL)-2-METHYLPROPANENITRILE 2-(4-HYDROXYPHENYL)-2-METHYLPROPANENITRILE

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Dexverapamil (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Dexverapami Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (aR)- (9CI) Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)- d-Verapamil (aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile Hydrochloride Dexverapamil Hydrochloride (R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile (αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile [R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)- 38321-02-7 C27H39ClN2O4 Intermediates & Fine Chemicals Pharmaceuticals