Toxoflavin
- CAS No.
- 84-82-2
- Chemical Name:
- Toxoflavin
- Synonyms
- Nsc 67078;Toxoflavin;PKF118-310;Brn 0021014;Toxoflavine;Toxinflavin;Xanthothricin;Toxoflavin (PKF118-310);1-MethylreuMycin, PKF118-310, Xanthrothricin;1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
- CBNumber:
- CB81252947
- Molecular Formula:
- C7H7N5O2
- Molecular Weight:
- 193.16
- MDL Number:
- MFCD00459812
- MOL File:
- 84-82-2.mol
- MSDS File:
- SDS
| Melting point | 165 °C |
|---|---|
| Boiling point | 276.7±23.0 °C(Predicted) |
| Density | 1.65±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble10mg/mL, clear |
| pka | -2.71±0.20(Predicted) |
| form | powder |
| color | white to light brown |
| EWG's Food Scores | 1 |
| FDA UNII | 5N5YI4IP1P |
Toxoflavin price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K4394 | PKF118-310 ≥98% (HPLC) | 84-82-2 | 5mg | $96.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | K4394 | PKF118-310 ≥98% (HPLC) | 84-82-2 | 25mg | $646 | 2024-03-01 | Buy |
| Cayman Chemical | 22440 | PKF118-310 ≥98% | 84-82-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 22440 | PKF118-310 ≥98% | 84-82-2 | 5mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 22440 | PKF118-310 ≥98% | 84-82-2 | 10mg | $254 | 2024-03-01 | Buy |
Toxoflavin Chemical Properties,Uses,Production
Uses
PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling.
Uses
Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.
Definition
ChEBI: Toxoflavin is a pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. It has a role as an antineoplastic agent, a toxin, a Wnt signalling inhibitor, an apoptosis inducer, a bacterial metabolite, an antibacterial agent and a virulence factor. It is a pyrimidotriazine and a carbonyl compound. It is functionally related to a reumycin.
Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.
Toxoflavin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
View Lastest Price from Toxoflavin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-27 | Toxoflavin
84-82-2
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
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- Toxoflavin
84-82-2
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co