4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- CAS No.
- 91526-18-0
- Chemical Name:
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
- Synonyms
- DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-
- CBNumber:
- CB82515847
- Molecular Formula:
- C5H6O4
- Molecular Weight:
- 130.1
- MDL Number:
- MFCD12165896
- MOL File:
- 91526-18-0.mol
Boiling point | 214℃ |
---|---|
Density | 1.367 |
Flash point | 93℃ |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | liquid |
pka | 14.54±0.10(Predicted) |
color | Pale yellow |
InChI | InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3 |
InChIKey | JEQSUJXHFAXJOW-UHFFFAOYSA-N |
SMILES | O1C(C)=C(CO)OC1=O |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
HS Code | 2932990090 |
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | H939928 | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one | 91526-18-0 | 50mg | $60 | 2021-12-16 | Buy |
SynQuest Laboratories | 2H25-1-2V | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97% | 91526-18-0 | 1g | $48 | 2021-12-16 | Buy |
Apolloscientific | OR927927 | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96% | 91526-18-0 | 1g | $30 | 2021-12-16 | Buy |
Apolloscientific | OR927927 | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 96% | 91526-18-0 | 5g | $110 | 2021-12-16 | Buy |
SynQuest Laboratories | 2H25-1-2V | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one 97% | 91526-18-0 | 5G | $176 | 2021-12-16 | Buy |
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Uses,Production
Description
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.
Definition
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.
Uses
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.
Preparation
At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 13606544505 | lucy@verychem.com | China | 1001 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-09-08 | 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
91526-18-0
|
US $0.00 / KG Ton | 1KG Ton | 95%+ | 2 tons/month | Zhuhai Hairuide Bioscience and Technology Co., Ltd | ||
2022-09-30 | 4-(hidroximetil)-5-metil-1,3-dioxol-2-one
91526-18-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2022-09-15 | 4-(Hydroxymethyl)-5-methyl-[1,3]dioxol-2-one
91526-18-0
|
US $30.00-28.00 / Kg | 1Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd |
- 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
91526-18-0
- US $0.00 / KG Ton
- 95%+
- Zhuhai Hairuide Bioscience and Technology Co., Ltd
- 4-(hidroximetil)-5-metil-1,3-dioxol-2-one
91526-18-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- 4-(Hydroxymethyl)-5-methyl-[1,3]dioxol-2-one
91526-18-0
- US $30.00-28.00 / Kg
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
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