PTEROIC ACID
- CAS No.
- 119-24-4
- Chemical Name:
- PTEROIC ACID
- Synonyms
- 4-(((2-AMino-4-oxo-3,4-dihydropteridin-6-yl)Methyl)aMino)benzoic acid;Pyrofolic acid;4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid;NSC 14972;PTEROIC ACID;Butterfly acid;Pteroic Acid (>Pteroic acid >=93%;Pteroic Acid (>85%);Folic acid iMpurity D
- CBNumber:
- CB8254618
- Molecular Formula:
- C14H12N6O3
- Molecular Weight:
- 312.28
- MDL Number:
- MFCD27967230
- MOL File:
- 119-24-4.mol
- MSDS File:
- SDS
Melting point | >400℃ |
---|---|
Boiling point | 610.0±65.0 °C(Predicted) |
Density | 1.69 |
storage temp. | 2-8°C |
solubility | Aqueous Base (Slightly), DMSO (Slightly) |
pka | 4.65±0.10(Predicted) |
color | Light Yellow to Brown |
FDA UNII | 8258W48TBZ |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P280-P261-P271 |
WGK Germany | 3 |
HS Code | 2933599590 |
PTEROIC ACID price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P1781 | Pteroic acid ≥93% | 119-24-4 | 25mg | $81.7 | 2024-03-01 | Buy |
Sigma-Aldrich | P1781 | Pteroic acid ≥93% | 119-24-4 | 50mg | $131 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2002 | Folic Acid Impurity D Pharmaceutical Secondary Standard; Certified Reference Material | 119-24-4 | 100mg | $647 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001243 | Folic acid impurity D European Pharmacopoeia (EP) Reference Standard | 119-24-4 | y0001243 | $220 | 2024-03-01 | Buy |
Sigma-Aldrich | P1781 | Pteroic acid ≥93% | 119-24-4 | 100mg | $255 | 2024-03-01 | Buy |
PTEROIC ACID Chemical Properties,Uses,Production
Uses
Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.
Uses
Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.
Definition
ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid.
General Description
Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Enzyme inhibitor
This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.
Purification Methods
Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]
PTEROIC ACID Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19536 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from PTEROIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-12-14 | Pteroic Acid
119-24-4
|
US $10.00 / g/Bag | 10g | 99 | 100KG | Wuhan Demeikai Biotechnology Co., Ltd | ||
2021-05-08 | Pteroic Acid
119-24-4
|
US $100.00 / KG | 1KG | 99% | 1000t | Hebei Minshang Biological Technology Co. LTD | ||
2019-07-06 | PTEROIC ACID
119-24-4
|
US $2.00 / KG | 1KG | 98% | 1ton | Career Henan Chemical Co |
- Pteroic Acid
119-24-4
- US $10.00 / g/Bag
- 99
- Wuhan Demeikai Biotechnology Co., Ltd
- Pteroic Acid
119-24-4
- US $100.00 / KG
- 99%
- Hebei Minshang Biological Technology Co. LTD
- PTEROIC ACID
119-24-4
- US $2.00 / KG
- 98%
- Career Henan Chemical Co
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